AI Article Synopsis
- - The study details the total synthesis of a potent antimalarial compound based on a benzo-pyranone framework, derived from the natural product (+)-monocerin found in marine fungi.
- - Key methods used in the synthesis include chiral hypervalent iodine(III)-catalyzed oxylactonization and late-stage methylation, which are crucial for creating the compound.
- - The researchers aimed to produce a library of all eight stereoisomers to better understand the relationship between stereochemistry and the compound's activity against malaria (S-SARs).
Article Abstract
This study presents a total synthesis and revision of the stereochemical configuration of a potent antimalarial lead compound possessing a benzo-pyranone framework, which was derived from the (+)-monocerin natural product of marine fungi, . Chiral hypervalent iodine(III)-catalyzed oxylactonization and late-stage -methylation were highlights of the synthesis, which enabled access to the library of all possible eight stereoisomers of for further understanding of stereochemical structure activity relationships (S-SARs).
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| http://dx.doi.org/10.1021/acs.orglett.4c02619 | DOI Listing |
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