AI Article Synopsis
- - This study explored how preoperative factors, especially muscle fat infiltration (measured as the skeletal muscle fat index), affect the outcomes of bariatric surgery in patients with morbid obesity.
- - In a group of 125 patients who underwent surgery, they found that those who lost at least 50% of excessive weight after one year had lower muscle fat infiltration and lower triglyceride and glycated hemoglobin levels before surgery.
- - The findings suggest that assessing myosteatosis could be important in predicting who will respond well to bariatric surgery, with lower baseline muscle fat being linked to better outcomes.
Article Abstract
Context: Data on the preoperative factors for bariatric surgery response in patients with morbid obesity are limited, and there are no studies on the relationship between myosteatosis and surgery response.
Object: We investigated the preoperative factors determining bariatric surgery response and the impact of preoperative muscle fat infiltration on bariatric surgery response.
Methods: This retrospective longitudinal cohort study included 125 individuals (37 men, 88 women) with morbid obesity who underwent bariatric surgery. Muscle fat infiltration (skeletal muscle fat index [SMFI]) was evaluated using computed tomography-based psoas muscle mass and density at the 4th lumbar level. A bariatric surgery response was defined as ≥50% excessive weight loss at one year postoperatively.
Results: Before bariatric surgery, the patient mean body weight and body mass index (BMI) were 107.0 kg and 39.0 kg/m2, respectively. After one year, the mean body weight was 79.6 kg. The mean excessive weight loss at one year was 75.6% and 102 (81.6%) patients were categorized as responders. There were no statistically significant differences in initial BMI, age, sex, or proportion of diabetes between responders and non-responders. Responders were more likely to have lower SMFI and triglyceride and glycated hemoglobin A1c levels than non-responders at baseline (P<0.05). Multiple logistic regression analysis showed that a lower baseline SMFI was associated with bariatric surgery response (odds ratio=0.31, 95% confidence interval=0.14-0.69, P=0.004).
Conclusions: Preoperative myosteatosis may determine the response to bariatric surgery.
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| http://dx.doi.org/10.1210/clinem/dgae567 | DOI Listing |
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