AI Article Synopsis
- - The review discusses the importance of amino acids for health, their roles in proteins, metabolism, and signaling, and highlights the use of physiologically based pharmacokinetic and pharmacodynamic (PBPK-PD) modeling to better understand amino acid functions.
- - Recent PBPK-PD models have provided insights into amino acid metabolism, including how leucine affects muscle protein metabolism and optimal supplementation strategies for conditions like sickle-cell disease and seizure disorders.
- - These models offer potential for future research in various areas, such as treatments for sarcopenia, comparisons between animal and plant-based nutrition, and understanding nutrient-drug interactions in diseases like Parkinson’s.
Article Abstract
Purpose Of Review: Amino acids are critical to health, serving both as constituents of proteins and in signaling and metabolism. Amino acids are consumed as nutrients, supplements, and nutraceuticals. Much remains to be learned about amino acid function. Physiologically based pharmacokinetic and pharmacodynamic (PBPK-PD) modeling is an emerging tool for studying their complex biology. This review highlights recent PBPK-PD models developed to study amino acid physiology and metabolism and discusses their potential for addressing unresolved questions in the field.
Recent Findings: PBPK-PD models provided several insights. They revealed the interplay between the mechanisms by which leucine governs skeletal muscle protein metabolism in healthy adults. The models also identified optimal dosing regimens of amino acid supplementation to treat sickle-cell disease and recurrent hypoglycemia, and to minimize drug side effects in seizure disorders. Additionally, they characterized the effects of novel anticancer drugs that seek to deprive cancer cells of amino acids. Future models may inform treatment strategies for sarcopenia, characterize distinctions between animal- and plant-based nutrition, and inform nutrient-drug interactions in Parkinson's disease.
Summary: PBPK-PD models are powerful tools for studying amino acid physiology and metabolism, with applications to nutrition, pharmacology, and their interplay.
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| http://dx.doi.org/10.1097/MCO.0000000000001067 | DOI Listing |
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