A veterinary pathologist, author, editor, teacher and mentor to many young vets and fish health professionals; he was a talented veterinarian who applied veterinary science to aquaculture.
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| http://dx.doi.org/10.1002/vetr.4635 | DOI Listing |
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Single-Frequency Birdcage Coils for Deep Tissue Perfluorocarbon Magnetic Resonance Imaging in Mice.
NMR Biomed
January 2025
Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada.
Fluorine-19 (F) MRI has become an established tool for in vivo cell tracking following ex vivo or in vivo labelling of various cell types with F perfluorocarbons (PFCs). Here, we developed and evaluated novel mouse-specific radiofrequency (RF) hardware for improved dual H anatomical imaging and deep tissue F MR detection of PFCs. Three linearly polarized birdcage RF coils were constructed-a dual-frequency H/F coil, and a pair of single-frequency H and F coils, designed to be used sequentially.
View Article and Find Full Text PDFPannexin 1 (PANX1) is upregulated in many cancers, where its activity and signalling promote tumorigenic properties. Here, we report a novel ∼25 kDa isoform of human PANX1 (hPANX1-25K) which lacks the N-terminus and was detected in several human cancer cell lines including melanoma, osteosarcoma, breast cancer and glioblastoma multiforme. This isoform was increased upon CRISPR/Cas9 deletion targeting the first exon near M1, suggesting a potential alternative translation initiation (ATI) site.
View Article and Find Full Text PDFProbing the effects of polysaccharide hydrogel composition on the viability and pro-angiogenic function of human adipose-derived stromal cells.
J Biomed Mater Res A
January 2025
School of Biomedical Engineering, Faculty of Engineering, The University of Western Ontario, London, Ontario, Canada.
Article Synopsis
- Cell therapies using mesenchymal stromal cells (MSCs), particularly human adipose-derived stromal cells (hASCs), are gaining attention as potential treatments for peripheral arterial disease (PAD) and critical limb ischemia (CLI), focusing on their ability to promote blood vessel growth.
- This study examined the effects of different natural polysaccharide hydrogels, specifically methacrylated glycol chitosan (MGC) and methacrylated hyaluronic acid (MHA), on the survival and pro-angiogenic functions of hASCs when encapsulated within them.
- Results showed that while hASCs maintained high viability in both hydrogels, those in MGC hydrogels secreted more pro-
Evaluation of DNA minicircles for delivery of adenine and cytosine base editors using activatable gene on "GO" reporter imaging systems.
Mol Ther Nucleic Acids
September 2024
Robarts Research Institute, University of Western Ontario, London, ON N6A 3K7, Canada.
Article Synopsis
- * CRISPR base editors, specifically adenine and cytosine base editors, can accurately alter DNA but face challenges with delivery efficiency and safety when using viral vectors.
- * This study introduces non-viral minicircles as a new delivery method for base editors, showing improved gene expression and luminescence signals compared to controls, and sets the stage for future research in cancer models.
Imaging CAR-NK cells targeted to HER2 ovarian cancer with human sodium-iodide symporter-based positron emission tomography.
Eur J Nucl Med Mol Imaging
September 2024
Department of Medical Biophysics, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Article Synopsis
- This study focuses on the development of HER2-targeted chimeric antigen receptor natural killer (CAR-NK) cells as a potential therapy for ovarian cancer, offering a less complex and more cost-effective alternative to traditional CAR T cell therapies.
- CAR-NK cells were genetically modified to express both a HER2-targeted CAR and a PET reporter gene, allowing for better tracking and imaging of these immune cells after administration.
- Experimental results demonstrated that CAR-NK cells were more effective in killing cancer cells, reducing tumor size and improving survival in mice, while also allowing for successful monitoring through bioluminescence and PET imaging techniques.
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