AI Article Synopsis
- The study investigates the role of hypermethylation of tumor suppressor genes located on chromosome 3p in the development of nasopharyngeal carcinoma (NPC), aiming to identify potential diagnostic biomarkers.
- Using biopsy samples and healthy specimens, it was found that a significant percentage of NPC tumors exhibited hypermethylation in several candidate genes, indicating an increased risk of cancer with an association between methylation status and NPC.
- The findings suggest that the methylation of these genes could effectively differentiate nasopharyngeal carcinoma from healthy tissues, particularly in advanced stages, making it a promising tool for diagnosis and monitoring of the disease.
Article Abstract
Background: The crucial event driving nasopharyngeal tumorigenesis is the hypermethylation of chromosome 3p-located tumor suppressor genes. This case-control study aims to investigate the methylation characteristics of , and to potentially develop effective diagnostic biomarkers for nasopharyngeal carcinoma, either individually or in combination.
Methods: The methylation of , , , and in the collection of 93 biopsy samples and 100 healthy swab specimens were evaluated by Nested methylation-specific polymerase chain reaction. The strength of the correlation between candidate genes and nasopharyngeal carcinoma was estimated by the evaluation of odds ratios (ORs).
Results: Promoter hypermethylation of , , , and were found in 60.22%, 80.65%, 62.37%, and 74.19%, respectively, in nasopharyngeal carcinoma tumors. A significant association between the methylation status of candidate genes with nasopharyngeal carcinoma was reported. The methylation of candidate genes significantly increased the risk of nasopharyngeal carcinoma in cancerous samples compared with control samples (OR > 1). Based on the value of the methylation index, methylation of at least one gene was found in 95.70% of nasopharyngeal tumors. Additionally, the methylation index among 93 tumors significantly correlated with advanced stage nasopharyngeal tumors.
Conclusion: The study explored a higher frequency of hypermethylation at least one candidate gene. Methylation of a panel of potential genes can be utilized to discriminate between nasopharyngeal carcinoma and non-cancer cells, particularly in the advanced stages of nasopharyngeal carcinoma. Thus, it could serve as a valuable marker for the diagnosis and monitoring of nasopharyngeal carcinoma.
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| http://dx.doi.org/10.1177/03936155241268431 | DOI Listing |
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