Approach to the patient with suspected hypotonic polyuria.

J Clin Endocrinol Metab

Georgetown-Howard Universities Center for Clinical and Translational Science, Georgetown University, Washington, DC 20007  USA.

Published: August 2024

Investigation and management of hypotonic polyura is a common challenge in clinical endocrinology. The three main causes, recently renamed to arginine vasopressin deficiency (AVP-D, formerly central diabetes insipidus), AVP-resistance (AVP-R, formerly nephrogenic diabetes insipidus), and primary polydipsia (PP) require accurate diagnosis as management differs for each. This new nomenclature more accurately reflects pathophysiology, and has now been adopted by the Systemised Nomenclature of Medicine (SNOMED). Advances in diagnosis over the last few years have centered around the use of copeptin measurement. Here, we use three patient case histories to highlight the use of this approach, and to demonstrate how it can succeed where other approaches, such as the water deprivation test, sometimes fail. We discuss the overall approach to each type of patient and the strengths and limitations of diagnostic strategies, illustrating the use of the new nomenclature.

Download full-text PDF

Source
http://dx.doi.org/10.1210/clinem/dgae565DOI Listing

Publication Analysis

Top Keywords

diabetes insipidus
8
approach patient
4
patient suspected
4
suspected hypotonic
4
hypotonic polyuria
4
polyuria investigation
4
investigation management
4
management hypotonic
4
hypotonic polyura
4
polyura common
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!