AI Article Synopsis
- Mitogen-activated extracellular signal-regulated kinase inhibitors (MEKi), like trametinib, show potential as a treatment for pediatric patients with low-grade gliomas, a type of brain tumor linked to abnormal MAP kinase pathway signaling.
- There is limited knowledge about the long-term effectiveness and side effects of these therapies specifically for children.
- The article discusses a unique case involving a young patient with a low-grade glioma who developed a rare skin infection caused by Mycobacterium chelonae while being treated with trametinib.
Article Abstract
Mitogen-activated extracellular signal-regulated kinase inhibitors (MEKi) represent a promising new therapy for pediatric patients with low-grade gliomas, which frequently have abnormal signaling within the mitogen-activated protein kinase (MAP kinase) pathway. However, understanding of long-term efficacy and toxicity is limited in pediatric glioma patients. This article describes a rare presentation of a widespread cutaneous infection with Mycobacterium chelonae in a pediatric patient with a low-grade glioma treated with trametinib.
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| http://dx.doi.org/10.1111/pde.15718 | DOI Listing |
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