AI Article Synopsis
- - A study investigated the effectiveness of terbinafine in treating sporotrichosis in cats, as its efficacy had not been previously established.
- - Out of 54 cats observed, only 10 were cured after an average of 18.5 weeks, with 18 treatment failures and some adverse reactions reported, including elevated liver enzymes.
- - High drop-out rates during the study limit the ability to make definitive conclusions about terbinafine's effectiveness, leading to the conclusion that it may not be a reliable treatment for feline sporotrichosis.
Article Abstract
Background: Terbinafine has been successfully used in the treatment of human sporotrichosis; however, its effectiveness in the treatment of feline sporotrichosis is unknown. Therefore, this study aimed to describe the use of terbinafine in the treatment of feline sporotrichosis.
Methods: A cohort study was conducted in cats with sporotrichosis to assess the effectiveness and safety of terbinafine (30‒60 mg/kg/day). Clinical examination and analysis of laboratory parameters were performed monthly until clinical signs resolved or terbinafine treatment was discontinued.
Results: Of the 54 cats with sporotrichosis included in the study, 19 were lost during follow-up and five were withdrawn from the study due to switching to treatment with another prescription drug. Of the remaining 30 cats, 10 achieved clinical cure, with a median treatment time of 18.5 weeks. Treatment failed in 18 cases, and two cats died. Twenty-two cats had adverse reactions to terbinafine treatment, and 10 cats showed elevation of serum transaminases.
Limitation: Loss during follow-up was high, which makes it difficult to draw accurate conclusions regarding clinical outcomes.
Conclusion: The low rate of clinical cure observed suggests that terbinafine does not represent an effective treatment option for cases of feline sporotrichosis.
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| http://dx.doi.org/10.1002/vetr.4435 | DOI Listing |
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