AI Article Synopsis
- - Chronic Kidney Disease (CKD) is a major health issue linked to Renal Fibrosis (RF), which is essential to tackle to prevent severe kidney damage (End-Stage Renal Disease).
- - The study identifies ADAMTS16 as a key factor in RF that enhances the activation of TGF-β, a protein that plays a significant role in kidney fibrosis progression.
- - Targeting ADAMTS16 could offer a new treatment approach for CKD by potentially reducing RF and improving patient outcomes.
Article Abstract
Chronic Kidney Disease (CKD) has emerged as a global public health concern, with its primary pathological basis being Renal Fibrosis (RF), crucial to halt its progression to End-Stage Renal Disease (ESRD). However, effective treatment options are currently lacking. Therefore, exploring the mechanisms of RF, identifying drug targets and diagnostic biomarkers are important. In this study, we identified ADAMTS16 as a newly expressed regulatory factor highly expressed in renal fibrosis tissue. ADAMTS16 interacts with latency-associated peptide (LAP)-transforming growth factor (TGF)-β, leading to the activation of TGF-β. Loss of ADAMTS16 expression effectively reduces TGF-β-dependent transcription activity. Furthermore, the use of RRFR tetrapeptide derived from ADAMTS16 can activate the TGF-β/Smad signaling axis, promoting RF. In summary, ADAMTS16 is induced in the progression of CKD, interacting with LAP-TGF-β and potentially activating SMAD2/3. Therefore, targeting ADAMTS16 may serve as a crucial new strategy to alleviate RF and treat CKD patients.
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| http://dx.doi.org/10.1016/j.cellsig.2024.111347 | DOI Listing |
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