AI Article Synopsis
- The study investigates the anticancer effects of flavonoids quercetin and chrysin on breast cancer cells (MCF-7 and MDA-MB-231), revealing their potential to inhibit cellular growth in a dose-dependent manner.
- Both compounds (especially when quercetin is preincubated) enhance cytotoxicity and induce cell cycle arrest in MDA-MB-231 cells, leading to increased apoptosis.
- The findings suggest that quercetin and chrysin can effectively work together to target breast cancer cells, warranting further exploration of their mechanisms and therapeutic applications.
Article Abstract
Pharmacological properties of flavonoids have been reported, with an anticancer role amongst them, however, its mechanisms are not fully elucidated. In this study, the activity of quercetin and chrysin towards MCF-7 and MDA-MB-231 breast cancer cells was investigated. Cellular viability was determined after treatment with the compounds in different concentrations for 24 h. Secondly, cells were treated with fixed concentration of chrysin and different concentrations of quercetin with preincubation for 1 h. Both compounds inhibited cellular proliferation in dose-dependent manner. The association showed improvement in their cytotoxicity, more expressively with preincubation of quercetin. Quercetin and chrysin association induced cell cycle arrest in sub-G0/G1 phase in MDA-MB-231 cells, modified the expression of caspases-3 and -8,-8, inducing late apoptosis cell death. Taken together, our results demonstrate that both flavonoids inhibited cells growth in a dose-dependent manner and the association of quercetin improved chrysin's toxic effect over the cell lines.
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| http://dx.doi.org/10.1016/j.biopha.2024.117276 | DOI Listing |
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