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Sequence analysis of the 5' region of the chymotrypsin C (CTRC) gene in chronic pancreatitis.
Pancreatology
January 2025
Center for Gastroenterology, Department of Medicine, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary; Hungarian Centre of Excellence for Molecular Medicine - University of Szeged, Translational Pancreatology Research Group, Szeged, Hungary. Electronic address:
Background/objectives: Loss-of-function chymotrypsin C (CTRC) variants increase the risk for chronic pancreatitis (CP) by reducing protective pancreatic CTRC activity. Variants in the 5' upstream region that includes the promoter might affect CTRC expression but have not been investigated to date. The aim of the present study was to address this knowledge gap.
View Article and Find Full Text PDFPhylogenetic analysis and homology modelling of a new Cry8A crystal protein expressed in a sporulating soil bacterium.
J Struct Biol
January 2025
Postgraduate Program in Industrial Biotechnology, Tiradentes University, Aracaju, Sergipe, Brazil; Department of Morphology, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil. Electronic address:
Cry proteins, commonly found in gram-positive soil bacteria, are used worldwide as aerial sprays or in transgenic plants for controlling crop pest populations and as insect vectors. Via PCR analysis, a spore producing soil isolate (BV5) was speculated to encode a Cry gene. Partial nucleotide sequence of the amplified PCR fragment showed homology with the Cry8 genes present in GenBank.
View Article and Find Full Text PDFEvolution and ecology of anti-defence systems in phages and plasmids.
Curr Biol
January 2025
Laboratory of Biochemistry, Wageningen University, 6708 WE Wageningen, The Netherlands. Electronic address:
Prokaryotes (Bacteria and Archaea) encode a highly diversified arsenal of defence systems that protect them against mobile genetic elements, such as phages and plasmids. In turn, mobile genetic elements encode anti-defence systems that allow them to escape the activity of these defence systems. This has resulted in an evolutionary arms race in which defence systems and anti-defence systems evolve and adapt continuously, driving intriguing innovation and enormous diversification on both sides.
View Article and Find Full Text PDFPreTKcat: A pre-trained representation learning and machine learning framework for predicting enzyme turnover number.
Comput Biol Chem
January 2025
College of Artificial Intelligence, Tianjin University of Science and Technology, No. 9, 13th Street, Tianjin Economic-Technological Development Area, Tianjin, 300457, China. Electronic address:
The enzyme turnover number (k) is crucial for understanding enzyme kinetics and optimizing biotechnological processes. However, experimentally measured k values are limited due to the high cost and labor intensity of wet-lab measurements, necessitating robust computational methods. To address this issue, we propose PreTKcat, a framework that integrates pre-trained representation learning and machine learning to predict k values.
View Article and Find Full Text PDFCitrus aurantium 'Changshan-huyou' physiological premature fruit drop: A promising prebiotic to tackle obesity.
Phytomedicine
December 2024
Hunan Agriculture Product Processing Institute; Dongting Laboratory; Hunan Academy of Agricultural Sciences, Changsha, Hunan Province 410125, China. Electronic address:
Background: Presently, the mitigation and governance of obesity have surfaced as significant public health dilemmas on a global scale. A wealth of studies indicated that the host gut microbiota is instrumental in regulating the interplay between high-fat diet (HFD) intake and the pathogenesis of obesity. Physiological premature fruit drop, a major byproduct of citrus, is rich in a variety of bioactive constituents, yet its potential has remained underutilized for an extended period.
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