AI Article Synopsis
- Animals need to find the right environment to survive, and special sensors help them detect humidity.* -
- A study shows that certain neurons in fruit flies change their behavior based on whether the flies are thirsty or not, helping them avoid too much moisture when they’re hydrated and seek it when they need water.* -
- The research reveals how different neurons work together to help flies find the right humidity level based on their need for water.*
Article Abstract
Survival in animals relies on navigating environments aligned with physiological needs. In , antennal ionotropic receptors (IRs) sensing humidity changes govern hygrotaxis behavior. This study sheds light on the crucial role of IR8a neurons in the transition from high humidity avoidance to water-seeking behavior when the flies become thirsty. These neurons demonstrate a heightened calcium response toward high humidity stimuli in satiated flies and a reduced response in thirsty flies, modulated by fluctuating levels of the neuropeptide leucokinin, which monitors the internal water balance. Optogenetic activation of IR8a neurons in thirsty flies triggers an avoidance response similar to the moisture aversion in adequately hydrated flies. Furthermore, our study identifies IR40a neurons as associated with dry avoidance, while IR68a neurons are linked to moist attraction. The dynamic interplay among these neurons, each with opposing valences, establishes a preference for approximately 30% relative humidity in well-hydrated flies and facilitates water-seeking behavior in thirsty individuals. This research unveils the intricate interplay between sensory perception, neuronal plasticity, and internal states, providing valuable insights into the adaptive mechanisms governing hygrotaxis in .
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11348324 | PMC |
| http://dx.doi.org/10.1073/pnas.2404454121 | DOI Listing |
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