Pemuchiamides A and B ( and ) were isolated from a marine sp. cyanobacterium collected from Pemuchi Beach on Hateruma Island, Japan. Although and existed as a complex mixture of rotamers in chloroform-, detailed analyses of their 2D NMR and tandem mass spectra revealed their planar structures, respectively. The absolute configurations of and were established via the degradation and derivatization reactions. Pemuchiamide A () exhibited potent growth-inhibitory activity against , the causative organism of African sleeping sickness, while showed 10-fold weaker activity than . This result indicates that the presence of a hydroxy group at the C-3 position of the 4-aminobutanoic acid moiety negatively affects antitrypanosomal activity.
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