AI Article Synopsis
- The study focuses on the single-nucleotide polymorphism (SNP) rs1333040 and its connection to coronary heart disease (CHD) in a Chinese population.
- Involving 500 CHD patients and 500 control subjects, the research employed case-control methods to analyze genotype differences and their statistical significance related to CHD risk.
- Findings suggest that the T allele of rs1333040 increases CHD risk, particularly in individuals with multiple risk factors, indicating a complex interplay between genetics and cholesterol levels in the disease's development.
Article Abstract
Background: Rs1333040 is the single-nucleotide polymorphisms (SNP) related with coronary heart disease (CHD). The aim of the present study is to examine the association between rs1333040 polymorphism genotypes and CHD and to further explore the molecular mechanism in Chinese population.
Methods: A case-control study was used in this study, including 500 CHD patients and 500 control subjects. CHD patients and controls were distinguished by coronary angiography. Genotypes of rs1333040 were determined on the Agena MassARRAY system. Statistical analysis was conducted by SPSS (Ver 16.0) and plink (Ver. 1.07, Shaun Purcell).
Results: Fisher's exact test by plink indicated a significant difference in the allele distribution between cases and controls, the allele T may be associated with a higher risk of CHD ( = 0.012, odds ratio (OR) = 1.258). The serum levels of low-density lipoprotein cholesterol (LDL-C) ( = 0.029) and Gensini score ( = 0.008) distributed differently in patients with various alleles. In the recessive model, the levels of high-density lipoprotein (HDL) and apolipoprotein A (ApoA) were higher in the TC + CC genotype than in the TT genotype. The TC + TT genotype was found to be risk factors against CHD in a dominant model (OR = 1.278, = 0.014). The TC + TT genotype along with multiple risk factors significantly positively correlated with the risk of CHD.
Conclusions: The present study investigates the association between the rs1333040 polymorphism genotypes and CHD. The T allele of rs1333040 is the susceptibility site of CHD. The interaction between SNP and various risk factors plays an important role in the development of CHD.
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| http://dx.doi.org/10.1080/00015385.2024.2391132 | DOI Listing |
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