AI Article Synopsis
- Various organ allografts show different levels of acceptance without immunosuppressive treatment, suggesting that understanding these differences is essential for managing immune responses.
- C57BL/6 mice can naturally accept DBA/2J kidney allografts, which develop tertiary lymphoid organs containing regulatory T cells vital for this acceptance.
- The study by Yokose and colleagues in the JCI highlights how these regulatory T cell-rich structures can convert harmful CD8+ T cells into exhausted or regulatory types through an IFN-γ-mediated process, offering insights that could improve graft acceptance rates.
Article Abstract
Various organ allografts differ in their propensity to be spontaneously accepted without any immunosuppressive treatment. Understanding the mechanisms behind these differences can aid in managing alloimmune responses in general. C57BL/6 mice naturally accept DBA/2J kidney allografts, forming tertiary lymphoid organs containing regulatory T cells (rTLOs), crucial for graft acceptance. In this issue of the JCI, Yokose and colleagues revealed that rTLOs promote conversion of cytotoxic alloreactive CD8+ T cells into exhausted/regulatory ones, through an IFN-γ-mediated mechanism. Their study provides insights into tolerance development that could help promote the acceptance of grafts at higher risk of rejection.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11324287 | PMC |
| http://dx.doi.org/10.1172/JCI183501 | DOI Listing |
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