AI Article Synopsis
- Iron deficiency is a significant issue for heart failure patients with left ventricular assist devices (LVAD), with prevalence rates between 40% and 82% found in studies.
- IV iron treatment is generally safe and can correct iron deficiency, but it is unclear how this affects survival or exercise capacity post-implant.
- Accurate diagnosis of iron deficiency may be challenging, suggesting the need for more rigorous clinical trials to understand its impact in LVAD patients better.
Article Abstract
Iron deficiency is a common and independent predictor of adverse outcomes in patients with heart failure. The implications of iron deficiency in patients implanted with a left ventricular assist device (LVAD) are less established. This review recaps data on the prevalence, characteristics and impact of Iron deficiency in the LVAD population. A systematic search yielded eight studies involving 517 LVAD patients, with iron deficiency prevalence ranging from 40% to 82%. IV iron repletion was not associated with adverse events and effectively resolved iron deficiency in most patients. However, the effects of iron deficiency and iron repletion on post-implant survival and exercise capacity remain unknown. Although iron deficiency is highly prevalent in LVAD patients, its true prevalence and adverse effects may be misestimated due to inexact diagnostic criteria. Future randomised controlled trials on IV iron treatment in LVAD patients are warranted to clarify the significance of this common comorbidity.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11322955 | PMC |
| http://dx.doi.org/10.15420/cfr.2023.26 | DOI Listing |
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