AI Article Synopsis
- When viruses infect cells, they change the cell's structure to create special areas called replication organelles (ROs) where they can copy their genetic material.
- Inside these ROs, special proteins called viral replicases help the virus make more of itself.
- Scientists are looking at these replicases as important targets for new medicines to fight viruses, and this summary talks about recent progress in developing these antiviral drugs.
Article Abstract
Viral infections usually induce the rearrangement of cellular cytoskeletal proteins and organelle membrane structures, thus creating independent compartments [termed replication organelles (ROs)] to facilitate viral genome replication. Within the ROs, viral replicases, including polymerases, helicases, and ligases, play functional roles during viral replication. These viral replicases are pivotal in the virus life cycle, and numerous studies have demonstrated that the viral replicases could be the potential targets for drugs development. Here, we summarize primarily the key replicases within viral ROs and emphasize the advancements of antiviral drugs targeting crucial viral replicases, providing novel insights into the future development of antiviral strategies.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11322364 | PMC |
| http://dx.doi.org/10.3389/fmicb.2024.1450060 | DOI Listing |
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