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Novel thermosensitive small multilamellar lipid nanoparticles with promising release characteristics made by dual centrifugation.
Eur J Pharm Sci
December 2024
Institute of Pharmaceutical Sciences, University of Freiburg, 79104 Freiburg im Breisgau, Germany; Andreas Hettich GmbH, 78532 Tuttlingen, Germany. Electronic address:
Thermosensitive liposomes (TSLs) have great potential for the selective delivery of cytostatic drugs to the tumor site with greatly reduced side effects. Here we report the discovery and characterization of new thermosensitive small multilamellar lipid nanoparticles (tSMLPs) with unusually high temperature selectivity. Furthermore, the temperature-dependent release of the fluorescent marker calcein from tSMLPs is enhanced by human serum albumin.
View Article and Find Full Text PDFDimer-monomer transition defines a hyper-thermostable peptidoglycan hydrolase mined from bacterial proteome by lysin-derived antimicrobial peptide-primed screening.
Elife
November 2024
Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.
Phage-derived peptidoglycan hydrolases (i.e. lysins) are considered promising alternatives to conventional antibiotics due to their direct peptidoglycan degradation activity and low risk of resistance development.
View Article and Find Full Text PDFInjectable, oxygen-releasing, thermosensitive hydrogel promotes vascularized bone formation with prolonged oxygen delivery and improved osteoinductivity.
Mater Today Bio
December 2024
Department of Orthopedic, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Article Synopsis
- The delay in healing critical bone defects is mainly caused by low oxygen levels and decreased bone-forming activity.
- This research developed an injectable hydrogel that releases oxygen and supports bone growth by integrating specific materials like calcium peroxide and nanoparticles.
- The hydrogel was tested on rats, showing improved bone regeneration and blood vessel formation after 8 weeks, highlighting its potential as a less invasive treatment for serious bone issues.
Discovery of thermosensitive Ca signals in embryonic turtle gonads.
Integr Zool
November 2024
College of Wildlife and Protected Area, Northeast Forestry University, Harbin, China.
Developing oxaliplatin and IL-15 Co-carried gels as drug depots to enable triple-interlocked combination therapy for colorectal cancer.
Colloids Surf B Biointerfaces
September 2024
Department of Pharmacy, Henan Provincial People's Hospital; People's Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan 450003, China. Electronic address:
Chemo-immunotherapy, which involves the simultaneous use of chemotherapy drug and immunotherapeutic agent to achieve synergistic effects, plays a crucial role in cancer treatment. However, the immunosuppressive microenvironment, insufficient tumor specificity, and serious systemic side effects hinder their synergistic therapeutic effects and clinical applications. Herein, T cell and natural killer (NK) cell, which are the most important immune effector cells, were both activated to reverse the immunosuppressive microenvironment.
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