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Umbilical cord-derived mesenchymal stem cells preferentially modulate macrophages to alleviate pulmonary fibrosis.
Stem Cell Res Ther
December 2024
State Key Laboratory of Membrane Biology, School of Basic Medical Sciencese, Institute of Precision Medicine, Tsinghua University, Beijing, 100084, China.
Background: Idiopathic Pulmonary Fibrosis (IPF) is a type of interstitial lung disease characterized by chronic inflammation due to persistent lung damage. Mesenchymal stem cells (MSCs), including those derived from the umbilical cord (UCMSCs) and placenta (PLMSCs), have been utilized in clinical trials for IPF treatment. However, the varying therapeutic effectiveness between these two MSC types remains unclear.
View Article and Find Full Text PDFPlacental and Fetal Metabolic Reprogramming in Pregnancies with Intrauterine Growth Restriction.
Reprod Sci
December 2024
Neonatology Unit, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.
The high-altitude hypoxia model demonstrates that insufficiently oxygenated placentas activate compensatory mechanisms to ensure fetal survival, hinging on the transcription factor hypoxia-inducible factor-1. The aim of the present study is to investigate whether and when similar mechanisms are also activated during intrauterine growth restriction (IUGR). A retrospective observational study evaluated a series of umbilical cord blood samples, which provide a realistic representation of the fetal intrauterine status, collected from a cohort of preterm and term neonates, both affected and not affected by IUGR.
View Article and Find Full Text PDFPlacenta-derived biomaterials vs. standard care in chronic diabetic foot ulcer healing: A systematic review and meta-analysis.
Diabetes Metab Syndr
December 2024
Department Nursing and Podiatry. Faculty of Health Sciences. University of Málaga, Malaga, Spain. Electronic address:
Introduction: This study explored the effectiveness of current placenta-derived biomaterials therapies in ulcer healing in DFU compared to standard of care (SOC).
Methods: The systematic review and meta-analysis were performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) standard. The electronic databases of PubMed, EMBASE, and Web of Science (WoS) internet were searched for the outcome rate of complete ulcer healing.
Umbilical and Placental Derivatives in Temporomandibular Joint Treatment: A Systematic Review.
J Clin Med
November 2024
National Medical Institute of the Ministry of Interior and Administration, Wołoska 137, 02-507 Warsaw, Poland.
: This review aimed to gather and summarize the existing information on the clinical application of allogeneic umbilical and placental derivatives in the treatment of temporomandibular joint disorders. : Research on the impact of the use of umbilical and placental derivatives on reducing pain and improving mobility in the temporomandibular joint was included in the article. Medical databases, including ACM, BASE, Cochrane, Scopus, Google Scholar, ClinicalTrials.
View Article and Find Full Text PDFTwin Anemia-Polycythemia Sequence With Spontaneous Resolution in Dichorionic Diamniotic Twin Pregnancy: A Case Report and a Review of the Literature.
Cureus
November 2024
Obstetrics and Gynecology, Kitasato University School of Medicine, Sagamihara, JPN.
Complications of twin pregnancy such as twin anemia-polycythemia sequence (TAPS), which involve placental anastomotic vessels, occur mostly in monochorionic diamniotic twins and they have rarely been reported in dichorionic diamniotic (DD) twins. Here, we report a case of DD twins diagnosed with TAPS with fetal hydrops caused by fetal anemia at 28 weeks, which resolved spontaneously during pregnancy. A 37-year-old pregnant woman was referred to our hospital because of a twin pregnancy at 13 weeks.
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