AI Article Synopsis
- Researching the similarities between granulomas in pulmonary tuberculosis (TB) and malignant tumors can lead to improved host-directed therapies (HDTs) for TB treatment.
- The article highlights how insights from cancer treatment can help tackle common issues in both conditions, like excessive fibrosis and immunosuppression.
- It suggests a new approach that combines HDTs with traditional anti-TB medications for better results while minimizing side effects and treatment duration.
Article Abstract
Exploring and exploiting the microenvironmental similarities between pulmonary tuberculosis (TB) granulomas and malignant tumors has revealed new strategies for more efficacious host-directed therapies (HDTs). This opinion article discusses a paradigm shift in TB therapeutic development, drawing on critical insights from oncology. We summarize recent efforts to characterize and overcome key shared features between tumors and granulomas, including excessive fibrosis, abnormal angiogenesis, hypoxia and necrosis, and immunosuppression. We provide specific examples of cancer therapy application to TB to overcome these microenvironmental abnormalities, including matrix-targeting therapies, antiangiogenic agents, and immune-stimulatory drugs. Finally, we propose a new framework for combining HDTs with anti-TB agents to maximize therapeutic delivery and efficacy while reducing treatment dosages, duration, and harmful side effects to benefit TB patients.
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| http://dx.doi.org/10.1016/j.molmed.2024.07.011 | DOI Listing |
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