AI Article Synopsis
- - A woman in her 20s was diagnosed with bulky stage II classic Hodgkin's lymphoma after experiencing symptoms like shortness of breath and cough for eight weeks, leading to the start of a chemotherapy regimen called ABVD.
- - During her treatment, she experienced severe hypertension and tonic-clonic seizures, which were diagnosed as posterior reversible encephalopathy syndrome (PRES), but this improved after stopping chemotherapy and managing her blood pressure.
- - The patient later developed anthracycline-induced cardiomyopathy, prompting a change in her chemotherapy to gemcitabine BVD, but she ultimately recovered fully and completed her treatment, achieving a complete metabolic response to the tumor.
Article Abstract
A woman in her 20s with no medical history was diagnosed with bulky stage II classic Hodgkin's lymphoma after an 8-week history of shortness of breath, cough and lethargy. A regimen of doxorubicin (Adriamycin), bleomycin, vinblastine and dacarbazine (ABVD) was commenced with six cycles planned. During the first cycle, the patient was profoundly hypertensive. She then suffered two self-terminating tonic-clonic seizures.Examination and investigations diagnosed posterior reversible encephalopathy syndrome (PRES), which resolved completely in 11 days with strict blood pressure control and withholding chemotherapy. Treatment was further complicated by anthracycline-induced cardiomyopathy, requiring a switch in regimen to gemcitabine BVD.The patient made a full recovery from neurology and cardiology perspectives and completed six cycles of chemotherapy, achieving a complete metabolic response by the tumour. We illustrate the case, describe differential diagnoses and management of PRES, its association with chemotherapy and the successful chemotherapy rechallenge.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11331916 | PMC |
| http://dx.doi.org/10.1136/bcr-2023-257523 | DOI Listing |
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