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"Macroscopy": A Proposal for More Inclusive and Accurate Terminology.
Arch Pathol Lab Med
October 2024
Graduate Medical Education Faculty, Aventura Hospital and Medical Center, Aventura, Florida.
Quality control in clinical raster-scan optoacoustic mesoscopy.
Photoacoustics
February 2024
Institute of Biological and Medical Imaging, Helmholtz Zentrum München, Neuherberg, Germany.
Optoacoustic (photoacoustic) mesoscopy bridges the gap between optoacoustic microscopy and macroscopy and enables high-resolution visualization deeper than optical microscopy. Nevertheless, as images may be affected by motion and noise, it is critical to develop methodologies that offer standardization and quality control to ensure that high-quality datasets are reproducibly obtained from patient scans. Such development is particularly important for ensuring reliability in applying machine learning methods or for reliably measuring disease biomarkers.
View Article and Find Full Text PDF"Macroscopy": A Proposal for More Inclusive and Accurate Terminology.
Arch Pathol Lab Med
October 2023
Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Hepatotoxic Evaluation of -(2-Hydroxyphenyl)-2-Propylpentanamide: A Novel Derivative of Valproic Acid for the Treatment of Cancer.
Molecules
August 2023
Laboratorio de Biofísica y Biocatálisis, Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Salvador Díaz Mirón s/n, Casco de Santo Tomas, Ciudad de México 11340, Mexico.
Article Synopsis
- Valproic acid (VPA) is associated with liver damage, but a new compound derived from it, HO-AAVPA, shows improved antiproliferative effects against cancer.
- A study on HO-AAVPA involved testing its effects on liver toxicity in rats and mice, with results indicating it has a higher median lethal dose (LD) than 2000 mg/kg and does not cause liver injury at therapeutic doses.
- Compared to VPA, HO-AAVPA led to fewer liver lesions and less disruption to liver enzyme levels, suggesting it could be a safer alternative for cancer treatment without the risk of hepatotoxicity.
Maize Internode Autofluorescence at the Macroscopic Scale: Image Representation and Principal Component Analysis of a Series of Large Multispectral Images.
Biomolecules
July 2023
UMR IATE, Univ Montpellier, INRAE, Institut Agro, 34060 Montpellier, France.
A quantitative histology of maize stems is needed to study the role of tissue and of their chemical composition in plant development and in their end-use quality. In the present work, a new methodology is proposed to show and quantify the spatial variability of tissue composition in plant organs and to statistically compare different samples accounting for biological variability. Multispectral UV/visible autofluorescence imaging was used to acquire a macroscale image series based on the fluorescence of phenolic compounds in the cell wall.
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