Wriggly woes: Helminths stirring up T cell trouble.

Immunity

Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

Published: August 2024

Understanding determinants of immune response variation is central to developing treatment options. Even et al. show that naive CD4 T cell transcriptional heterogeneity is altered by helminth infection leading to impaired immune responses independent of commensals.

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Source
http://dx.doi.org/10.1016/j.immuni.2024.07.014DOI Listing

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