The active state of individuals has a significant impact on disease spread dynamics. In addition, pairwise interactions and higher-order interactions coexist in complex systems, and the pairwise networks proved insufficient for capturing the essence of complex systems. Here, we propose a higher-order network model to study the effect of individual activity level heterogeneity on disease-spreading dynamics. Activity level heterogeneity radically alters the dynamics of disease spread in higher-order networks. First, the evolution equations for infected individuals are derived using the mean field method. Second, numerical simulations of artificial networks reveal that higher-order interactions give rise to a discontinuous phase transition zone where the coexistence of health and disease occurs. Furthermore, the system becomes more unstable as individual activity levels rise, leading to a higher likelihood of disease outbreaks. Finally, we simulate the proposed model on two real higher-order networks, and the results are consistent with the artificial networks and validate the inferences from theoretical analysis. Our results explain the underlying reasons why groups with higher activity levels are more likely to initiate social changes. Simultaneously, the reduction in group activity, characterized by measures such as "isolation," emerges as a potent strategy for disease control.
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http://dx.doi.org/10.1063/5.0207855 | DOI Listing |
JMIR Res Protoc
March 2025
Paseo de los Encomendadores, Faculty of Health Sciences, University of Burgos, Burgos, Spain.
Background: Breast cancer is the second most common cancer in women worldwide. Treatments for this disease often result in side effects such as pain, fatigue, loss of muscle mass, and reduced quality of life. Physical exercise has been shown to effectively mitigate these side effects and improve the quality of life in patients with breast cancer.
View Article and Find Full Text PDFPLoS One
March 2025
Faculty of Education, Mie University, Mie, Japan.
This study is the first in Japan to prospectively examine the relationship between walking to and from school and physical activity in primary school children. A total of 76 participants completed baseline and follow-up assessments, and their mean age was 9.6 ± 1.
View Article and Find Full Text PDFJ Osteopath Med
March 2025
Wood College of Osteopathic Medicine, Marian University, Indianapolis, IN, USA.
Context: Sarcopenia is a disease characterized by low muscle mass and function that places individuals at greater risk of disability, loss of independence, and death. Current therapies include addressing underlying performance issues, resistance training, and/or nutritional strategies. However, these approaches have significant limitations, and chronic inflammation associated with sarcopenia may blunt the anabolic response to exercise and nutrition.
View Article and Find Full Text PDFJ Immunol
January 2025
Center for Translational Immunology, Benaroya Research Institute, Seattle, WA, United States.
The CD2-depleting drug alefacept (LFA3-Ig) preserved beta cell function in new-onset type 1 diabetes (T1D) patients. The most promising biomarkers of response were late expansion of exhausted CD8 T cells and rare baseline inflammatory islet-reactive CD4 T cells, neither of which can be used to measure responses to drug in the weeks after treatment. Thus, we investigated whether early changes in T cell immunophenotypes could serve as biomarkers of drug activity.
View Article and Find Full Text PDFJ Immunol
January 2025
Division of Infectious Diseases, Center for Inflammation and Tolerance, Department of Pediatrics, Cincinnati Children's Hospital, University of Cincinnati College of Medicine, Cincinnati, OH, United States.
Organ transplant recipients require continual immune-suppressive therapies to sustain allograft acceptance. Although medication nonadherence is a major cause of rejection, the mechanisms responsible for graft loss in this clinically relevant context among individuals with preceding graft acceptance remain uncertain. Here, we demonstrate that skin allograft acceptance in mice maintained with clinically relevant immune-suppressive therapies, tacrolimus and mycophenolate, sensitizes hypofunctional PD1hi graft-specific CD8+ T cells.
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