AI Article Synopsis
- Adult T-cell acute lymphoblastic leukemia (T-ALL) has a low survival rate after it relapses, particularly the early T-cell precursor subtype, which shares similarities with acute myeloid leukemia.
- A case study is presented where a patient relapsed just 3 months post allogeneic stem cell transplantation but achieved complete remission through treatment with azacitidine and has remained on therapy for 9 years.
- The discussion highlights the biological factors contributing to this long-term response and explores the potential benefits of combining hypomethylating agents like azacitidine with other drugs, such as venetoclax, for improved outcomes.
Article Abstract
Adult T-cell acute lymphoblastic leukemia has a poor outcome after relapse. Because the subtype of early T-cell precursor displays characteristics close of those of acute myeloid leukemia, such as epigenetic dysregulation, hypomethylating agents might prove of interest. We describe the case of a patient relapsing 3 months only after allogeneic stem cell transplantation who achieved complete remission on azacitidine, and is still on therapy 9 years later. We discuss the biological background of this very long-term response, underlining the immunological effects of hypomethylating agents, and the perspectives opened by combination of hypomethylating agents with other drugs such as venetoclax.
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| http://dx.doi.org/10.1080/10428194.2024.2390572 | DOI Listing |
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