AI Article Synopsis
- There are differences in bioactivity among various forms of vitamin K (VK), which impact anticoagulation therapy.
- A study established a method to measure levels of VK1 and two forms of VK2 (MK-4 and MK-7) in plasma samples from cardiovascular patients.
- Results showed that concentrations of MK-7 and total VKs were significantly associated with initial anticoagulation levels (INR0), suggesting these vitamin K forms should be considered when adjusting anticoagulation doses.
Article Abstract
Differences are existed in the bioactivity among various vitamin K (VK) forms. To investigate the correlation between clinical parameters of initial anticoagulation and plasma levels of VK1 and VK2 (MK-4 and MK-7), it was necessary to establish a quantitative method for simultaneous determination. Plasma samples in cardiovascular patients were extracted by cyclohexane and analyzed using a C18 column. Baseline concentrations of VK1, MK-4 and MK-7 were 0.98 ± 0.52 ng/ml, 0.45 ± 0.13 ng/ml and 0.65 ± 0.31 ng/ml, respectively. The concentrations of MK-7 and total VKs were significantly relevant to INR0, respectively (p = 0.010 and p = 0.048, respectively). Thus, when adjusting anticoagulation dosage, concentrations of various VK homologues might be considered.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11485696 | PMC |
| http://dx.doi.org/10.1080/17576180.2024.2383109 | DOI Listing |
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