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Prognostic value of immune biomarkers in melanoma loco-regional metastases.
PLoS One
January 2025
Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway.
The prognosis for patients with melanoma loco-regional metastases is very heterogenous. Adjuvant PD-L1-inhibitors have improved clinical outcome for this patient group, but the prognostic impact of tumour PD-L1 expression and number of tumour infiltrating lymphocytes (TILs) is still largely unknown. Here, we investigated the impact on survival for CD3, CD8, FOXP3 and PD-L1 TIL counts and tumour PD-L1 expression in melanoma loco-regional metastases.
View Article and Find Full Text PDFLiquid slide electrification: advances and open questions.
Soft Matter
January 2025
Institute for Photovoltaics, University of Stuttgart, Pfaffenwaldring 47, 70569 Stuttgart, Germany.
This review is about drops of a liquid with high dielectric permittivity that slide over a solid surface with high electrical resistivity. A typical situation is a water drop sliding down a tilted hydrophobic plate. It has been realized recently that such drops spontaneously acquire a charge.
View Article and Find Full Text PDFDesign, modeling, and control of coaxial integrated macro-micro composite actuator with high-precision and long-stroke.
Rev Sci Instrum
January 2025
School of Mechatronics Engineering, Anhui University of Science and Technology, Huainan 232001, China.
This paper presents a coaxial integrated macro-micro composite actuator. The macro-actuator of the macro-micro composite actuator is similar to a moving coil type voice coil motor, and a giant magnetostrictive actuator is installed coaxially inside it as a micro-actuator. In this work, kinetic models are established for both the macro-actuator and micro-actuator, and based on the models, an automatic disturbance rejection controller is adopted to control the macro-actuator, and a fuzzy sliding mode controller is adopted for the micro-actuator.
View Article and Find Full Text PDFTrochanteric hip fractures treated surgically-outcome in a ten-year cohort of 46,121 patients from the Swedish National Hip Fracture Registry.
OTA Int
March 2025
Department of Orthopedic Surgery, Orebro University Hospital & School of Medical Sciences, Orebro University, Orebro, Sweden.
Objectives: To compare postoperative mortality regarding 2 techniques in the treatment of trochanteric hip fractures (THFs).
Design: Retrospective cohort study.
Setting: National databases.
Developing a Novel Integrative Health Equity and Anti-racism Tool (IHEART) for Pilot Application in a Multicenter Integrative Health Elective for Medical Students and Resident Physicians: A Study Protocol.
Glob Adv Integr Med Health
January 2025
Harvard Medical School, Boston, MA, USA.
Background: This study protocol introduces the Integrative Health Equity and Anti-Racism Tool (IHEART), an innovative instrument designed to infuse equity, diversity, and inclusion (EDI) into Integrative Health (IH) education. Recognizing the gaps in current IH training that fail to address social and systemic inequities adequately, the IHEART is intended to respond to the growing need for inclusivity in IH practices and educational materials. The tool is mainly focused on addressing issues such as accessibility of complementary and integrative health (CIH) therapies, cultural misappropriation, anti-racism, gender diversity, disability justice, trauma-informed care, weight inclusivity, and planetary health, which are currently inconsistently covered in IH training.
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