AI Article Synopsis
- A five-year-old girl with short gut syndrome and long-term TPN dependence experienced two non-fatal central line-associated bloodstream infections (CLABSI) over a span of 15 months, with no signs of ongoing mold infections in between the episodes.
- Both infections were managed by removing the infected central venous catheter and administering 6 weeks of antifungal treatment, leading to positive clinical outcomes.
- This case highlights the unique aspects of recurrent blood culture positive mucormycosis, suggesting that the bloodstream infections may behave differently compared to invasive mucormycosis from other fungal species.
Article Abstract
A five year old girl with life-long TPN dependence for short gut syndrome presented with two episodes of non-fatal central line associated blood stream infection (CLABSI). Each episode occurred fifteen months apart, without any evidence of ongoing mould infection whilst off antifungal therapy in the intervening time period. Both episodes were treated with removal of the infected central venous catheter (CVC) and 6 weeks of intravenous liposomal amphotericin B and/or posaconazole, with good clinical, microbiological, and radiological response. The possibility of gut translocation is supported by the repeated isolation of in cases of intestinal mucormycosis. To our knowledge, this is the first case of recurrent episodes of blood culture positive mucormycosis in a single patient. blood stream infection may differ significantly from invasive mucormycosis caused by other species.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11321366 | PMC |
| http://dx.doi.org/10.1016/j.mmcr.2024.100661 | DOI Listing |
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