In this study, a model was developed to simulate the effect of temperature ( ) and initial substrate concentration ( ) on the ethanol concentration limit ( ) using the yeast Saccharomyces cerevisiae. To achieve this, regressions were performed using data provided by other authors for to establish a model dependent on and capable of predicting results with statistical significance. After constructing the model, a response surface was generated to determine the conditions where reaches higher values: temperatures between 28°C and 32°C and an initial substrate concentration around 200 g/L. Thus, the proposed model is consistent with the observations that increasing temperatures decrease the ethanol concentration obtained, and substrate concentrations above 200 g/L lead to a reduction in ethanol concentration even at low temperatures such as 28°C.
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http://dx.doi.org/10.1002/bit.28771 | DOI Listing |
Acta Parasitol
January 2025
Department of Molecular Biology and Genetics, Ordu University, Ordu, Turkey.
Purpose: Acanthamoeba species are eucaryotic protozoa found predominantly in soil and water. They cause ulceration and vision loss in the cornea (Acanthamoeba keratitis) and central nervous system (CNS) infection involving the lungs (granulomatous amoebic encephalitis). Antiparasitic drugs currently used in the treatment of infections caused by Acanthamoeba species are not effective at the desired level in some anatomical regions such as the eye and CNS.
View Article and Find Full Text PDFMol Biol Rep
January 2025
Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Background: The traditional use of Moringa oleifera (MO), an essential food source in Africa and Asia, to cure various diseases dates back thousands of years. This study examines the aqueous and ethanolic leaf extracts of MO's in vitro anti-leukemia capabilities.
Methods: After preparing aqueous and ethanolic MO leaf extracts, cells were treated with various concentrations for 48 h.
Pharm Biol
December 2025
Laboratory of Pharmacology, Chulabhorn Research Institute, Bangkok, Thailand.
Aim: Insufficient quality control and limited dissolution of extract capsules restricts their bioavailability and hinder the clinical use for treating mild coronavirus disease 2019 (COVID-19) patients.
Objective: This study aims to investigate pharmacokinetics and safety of high-dosage ethanolic extract (equivalent to 180 or 360 mg/day of andrographolide), relevant dosages used for mild COVID-19 treatment.
Methods: An open-label, single-dose, and repeated-dose conducted in healthy volunteers.
Prev Nutr Food Sci
December 2024
Toxicology and Environmental Research Group-BIOTOXAM, Faculty of Medicine, Universidad de Cartagena, Cartagena 130015, Colombia.
In Colombia, there is a long tradition of using bijao () leaves to package or wrap various foods. However, scientific studies on are limited, and research to evaluate its toxicity and/or antibacterial activity has not yet been conducted. The objective of this research, therefore, was to evaluate the content of phytochemical compounds, levels of toxicity, and antibacterial activity of the extracts, fractions, and essential oil derived from leaves.
View Article and Find Full Text PDFHeliyon
December 2024
Department of Biomedical Sciences, Institute of Health, Jimma University, Ethiopia.
The global food system is plagued by legitimacy and stability issues due to climate and ecosystem disruptions, contributing to widespread malnutrition. A significant portion of the global population experiences undernourishment, overweight, and micronutrient deficiencies from unhealthy diets. Addressing these challenges necessitates regular consumption of essential nutrients from plant sources.
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