Novel microwave assisted carboxymethyl-graphene oxide and its hepatoprotective activity.

BMC Pharmacol Toxicol

Cellulose and Paper Department, National Research Centre, 33 El Bohouth Str., P.O. 12622, Dokki, Giza, Egypt.

Published: August 2024

AI Article Synopsis

  • Scientists found a new, eco-friendly way to make a special type of graphene oxide (CMGO) using leftovers from sugarcane quickly and cheaply.
  • Tests showed this CMGO can help reduce harmful substances and improve liver function in damaged cells caused by toxic materials.
  • This research suggests that using CMGO could be a great and affordable way to help protect our bodies from toxins.

Article Abstract

This study reports a novel, eco-friendly; fast and cost-effective microwave method for synthesizing carboxymethylated graphene oxide (CMGO) from sugarcane residues. Fourier-transform infrared spectroscopy (FTIR) confirmed successful CMGO synthesis through the presence of characteristic peaks at 1567.93 and 1639.29 cm (COONa vibrations) and increased CH intensity compared to unmodified graphene oxide (GO). Furthermore, CMGO derived from sugarcane residues demonstrated potential in mitigating the side effects of toxic materials like carbon tetrachloride (CCl). Treatment with CMGO partially reduced elevated levels of liver enzymes (ALT and AST) and nitrogenous waste products (urea and uric acid) in CCl-induced liver damage models, suggesting an improvement in liver function despite ongoing cellular damage.This work paves the way for a sustainable and economical approach to produce functionalized graphene oxide with promising biomedical applications in alleviating toxin-induced liver injury.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11321068PMC
http://dx.doi.org/10.1186/s40360-024-00768-0DOI Listing

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