AI Article Synopsis
- The study aimed to explore the causal relationship between skin microbiota, particularly Propionibacterium acnes, and conditions like intervertebral disc degeneration (IVDD), low back pain (LBP), and sciatica using two-sample Mendelian randomization.
- Researchers analyzed data from genome-wide association studies (GWAS) to discover associations between various skin microbiota and the aforementioned conditions, finding specific bacteria linked to both risks and protective factors against IVDD, LBP, and sciatica.
- The findings suggest a complex relationship; while certain skin bacteria, like P.acnes, may not be risk factors for these conditions, IVDD might actually lead to increased levels of P.acnes, implying that skin
Article Abstract
Objective: The purpose of this study is to use two-sample Mendelian randomization (MR) to investigate the causal relationship between skin microbiota, especially Propionibacterium acnes, and intervertebral disc degeneration (IVDD), low back pain (LBP) and sciatica.
Methods: We conducted a two-sample MR using the aggregated data from the whole genome-wide association studies (GWAS). 150 skin microbiota were derived from the GWAS catalog and IVDD, LBP and sciatica were obtained from the IEU Open GWAS project. Inverse-variance weighted (IVW) was the primary research method, with MR-Egger and Weighted median as supplementary methods. Perform sensitivity analysis and reverse MR analysis on all MR results and use multivariate MR to adjust for confounding factors.
Results: MR revealed five skin microbiota associated with IVDD, four associated with LBP, and two with sciatica. Specifically, P.acnes in sebaceous skin environments were associated with reduced risk of IVDD; IVDD was found to increase the abundance of P.acnes in moist skin. Furthermore, ASV010 [Staphylococcus (unc.)] from dry skin was a risk factor for LBP and sciatica; ASV045 [Acinetobacter (unc.)] from dry skin and Genus Rothia from dry skin exhibited potential protective effects against LBP; ASV065 [Finegoldia (unc.)] from dry skin was a protective factor for IVDD and LBP. ASV054 [Enhydrobacter (unc.)] from moist skin, Genus Bacteroides from dry skin and Genus Kocuria from dry skin were identified as being associated with an increased risk of IVDD. Genus Streptococcus from moist skin was considered to be associated with an increased risk of sciatica.
Conclusions: This study identified a potential causal relationship between skin microbiota and IVDD, LBP, and sciatica. No evidence suggests skin-derived P.acnes is a risk factor for IVDD, LBP and sciatica. At the same time, IVDD can potentially cause an increase in P.acnes abundance, which supports the contamination theory.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11321032 | PMC |
| http://dx.doi.org/10.1186/s13018-024-04980-w | DOI Listing |
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