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Revisiting the concept of giant viruses.
Microbes Infect
December 2024
Laboratório de Vírus, Departamento de Microbiologia, Universidade Federal de Minas Gerais (UFMG). Belo Horizonte, Minas Gerais, 31270-901, Brazil. Electronic address:
Giant viruses have fascinated the scientific community due to their immense particles and extensive genomes. A significant surge of interest in the field has been observed over the past 20 years following the discovery of mimiviruses, the first amoeba-infecting viruses described. However, with the discovery of new amoeba viruses and those from other protists, the concept of "giant viruses" has become increasingly controversial in the scientific literature.
View Article and Find Full Text PDFExploring opposing arguments in the call for randomized controlled trials to demonstrate benefit of Mohs micrographic surgery for cutaneous melanoma.
Dermatol Online J
October 2024
Department of Dermatology, Mayo Clinic, Rochester, Minnesota, USA Division of Dermatologic Surgery, Mayo Clinic, Rochester, Minnesota, USA.
The call for robust randomized clinical trials (RCTs) comparing Mohs micrographic surgery (MMS) with wide local excision for treatment of melanoma has stymied the development of guidelines for MMS despite growing evidence of benefit. This commentary explores the controversy by detailing opposing arguments, reviewing the relevant evidence supporting the use of MMS for early-stage melanoma, and discussing the role that RCTs may play in development of national guidelines for surgical treatment options for melanoma. Randomized clinical trials are considered the gold standard of clinical research, but there are no such trials currently to support MMS for melanoma.
View Article and Find Full Text PDFAnisogamy and sex roles: a commentary.
Evol Lett
December 2024
Department of Life Sciences, Milner Centre for Evolution, University of Bath, Bath BA2 7AY, United Kingdom.
The origin and maintenance of sex differences in reproductive behavior (often labeled sex roles) have remained controversial topics, and recent meta-analyses and theoretical models have helped to elucidate the processes that generate diverse sex roles. We are glad to see that our study (Mokos et al., 2021) generated a healthy debate, and in agreement with recent commentaries (Janicke, 2024; Lehtonen & Parker, 2024) we call for a more comprehensive approach to understanding sex role evolution.
View Article and Find Full Text PDFPediatric obesity and treatment controversies: Is the use of medications too good to be true?
Am J Health Syst Pharm
December 2024
Kentucky Children's Hospital at UK HealthCare, Lexington, KY, USA.
In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time.
View Article and Find Full Text PDFUnpacking the Controversies of Weight Loss and Dietary Restraint With Binge-Eating Disorder: Commentary on Grilo and Pittman.
Int J Eat Disord
November 2024
Department of Psychiatry and Human Behavior, Brown University; Weight Control and Diabetes Research Center, the Miriam Hospital, Providence, Rhode Island, USA.
The study by Grilo and Pittman highlights two related controversies affecting the eating disorders field: (1) Is it ever appropriate to recommend behavioral weight loss (BWL) interventions to patients with binge-eating disorder (BED); and (2) Is dietary restraint beneficial or harmful? This paper explores reasons underlying these controversies and underscores the important nuances within these constructs within the context of Grilo and Pittman's findings. For example, people often subsume BWL as part of the umbrella term "dieting," but extensive research shows clear differences between self-directed "dieting" and BWL intervention on both weight loss efficacy and on eating disorder psychopathology. In addition, it is critical to consider and understand the different types of dietary restraint.
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