AI Article Synopsis
- Excessive formation of macrophage extracellular traps (METs) has been linked to autoimmune diseases, but their role in Type 1 Diabetes (T1D) is not well understood.
- The study highlights the importance of the enzyme peptidyl arginine deiminase 4 (PAD4) in promoting METs and pro-inflammatory M1 macrophages, which exacerbates intestinal inflammation in non-obese diabetic (NOD) mice.
- Inhibition of METs formation could be a potential therapeutic strategy for T1D, as it affects the migration of pro-inflammatory T cells from the intestine to the pancreas.
Article Abstract
Excessive formation of macrophage extracellular trap (MET) has been implicated in several autoimmune disease pathogeneses; however, its impact on type 1 diabetes (T1D) and related mechanisms remains enigmatic. We demonstrated the pivotal role of peptidyl arginine deiminase 4 (PAD4) in driving profuse MET formation and macrophage M1 polarization in intestinal inflammation in NOD mice. Genetic knockout of PAD4 or adoptive transfer of METs altered the proportion of proinflammatory T cells in the intestine, subsequently influencing their migration to the pancreas. Combining RNA sequencing and CUT&Tag analysis, we found activated PAD4 transcriptionally regulated CXCL10 expression. This study comprehensively investigated how excessive PAD4-mediated MET formation in the colon increases the aggravation of intestinal inflammation and proinflammatory T-cell migration and finally is involved in T1D progression, suggesting that inhibition of MET formation may be a potential therapeutic target in T1D.
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| http://dx.doi.org/10.2337/db23-1000 | DOI Listing |
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