Natural ion channels are proteins embedded in the cell membrane that control many aspects of cell and human physiology by acting as gatekeepers, regulating the flow of ions in and out of cells. Advances in nanotechnology have influenced the methods for studying ion channels , as well as ways to unlock the delivery of therapeutics by modulating them . This review provides an overview of nanotechnology-enabled approaches for ion channel research with a focus on the synthesis and applications of synthetic ion channels. Further, the uses of nanotechnology for therapeutic applications are critically analyzed. Finally, we provide an outlook on the opportunities and challenges at the intersection of nanotechnology and ion channels. This work highlights the key role of nanoscale interactions in the operation and modulation of ion channels, which may prompt insights into nanotechnology-enabled mechanisms to study and exploit these systems in the near future.
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http://dx.doi.org/10.1021/acsnano.4c05654 | DOI Listing |
J Taibah Univ Med Sci
February 2025
Department of Prosthodontics/Dental Material, Dr. Ziauddin Ahmad Dental College, Aligarh Muslim University, India.
Objectives: Calcium ions (Ca) play crucial role in tooth development, particularly in maintaining enamel density during amelogenesis. Ameloblasts require specific proteins such as amelogenin, ameloblastin, enamelin, kallikrein, and collagen for enamel growth. Recent research has highlighted the importance of calcium and fluoride ions, as well as the TRPM7, STIM, and SOCE pathways, in regulating various stages of enamel formation.
View Article and Find Full Text PDFEcol Evol
January 2025
Hunan Provincial Key Laboratory of Ecological Conservation and Sustainable Utilization of Wulingshan Resources College of Biology and Environmental Sciences, Jishou University Jishou Hunan China.
Karst caves are a unique environment significantly different from the external environment; adaptation of cave-dwelling animals to the cave environment is often accompanied by shifts in the sensory systems. Aquatic and terrestrial leeches have been found in the karst caves. In this study, we conducted a transcriptome analysis on the cave-dwelling leech .
View Article and Find Full Text PDFNanoscale
January 2025
College of Science, China Agricultural University, Beijing, 100083, China.
Aqueous zinc-ion batteries are an appealing electrochemical energy storage solution due to their affordability and safety. Significant attention has been focused on vanadium oxide cathode materials for ZIBs, owing to their high specific capacity, unique layered or tunnel structures, and low cost. Compared to traditional methods for preparing and assembling electrode materials, direct current (DC) magnetron sputtering allows direct synthesis and uniform deposition on current collectors, offering advantages such as simplicity, mild reaction conditions, and strong film adhesion.
View Article and Find Full Text PDFCurr Cardiol Rev
January 2025
Department of Cardiology, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China.
Background: Supraventricular tachycardia (SVT) is very common in daily clinical practice, especially in the emergency department, with rapid onset and urgent management. The review highlights the recent genetic predispositions and mechanisms in SVT.
Methods: Through analysis of epidemiology, familial clustering, and gene mutations of the relevant literatureļ¼the review elucidates the genetic properties and potential pathophysiology of SVT.
Sci Rep
January 2025
Emergency department, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, Hebei, China.
Esophageal squamous cell carcinoma (ESCC) is one of the most common digestive malignancies. Our previous studies revealed necroptosis-related lncRNA ENSG00000253385.1 was an independent prognostic factor for ESCC.
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