Using Nanoscale Passports To Understand and Unlock Ion Channels as Gatekeepers of the Cell.

ACS Nano

Department of Biomedical Engineering, Faculty of Engineering and Information Technology, The University of Melbourne, Parkville, VIC 3010, Melbourne, Australia.

Published: August 2024

AI Article Synopsis

  • * Scientists are using new technology called nanotechnology to study these channels better and even create synthetic ones that can be used for medicine.
  • * The review discusses both the cool ways nanotechnology helps us understand ion channels and the challenges we might face in using these new methods in the future.

Article Abstract

Natural ion channels are proteins embedded in the cell membrane that control many aspects of cell and human physiology by acting as gatekeepers, regulating the flow of ions in and out of cells. Advances in nanotechnology have influenced the methods for studying ion channels , as well as ways to unlock the delivery of therapeutics by modulating them . This review provides an overview of nanotechnology-enabled approaches for ion channel research with a focus on the synthesis and applications of synthetic ion channels. Further, the uses of nanotechnology for therapeutic applications are critically analyzed. Finally, we provide an outlook on the opportunities and challenges at the intersection of nanotechnology and ion channels. This work highlights the key role of nanoscale interactions in the operation and modulation of ion channels, which may prompt insights into nanotechnology-enabled mechanisms to study and exploit these systems in the near future.

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Source
http://dx.doi.org/10.1021/acsnano.4c05654DOI Listing

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