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In vitro and Ex vivo Assessments of the Compatibility of Fibrin Sealant with Antimicrobial Compounds.
Surg Infect (Larchmt)
February 2023
Ludwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA, Vienna, Austria.
Fibrin sealants are used as antimicrobial-releasing carriers for preventing surgical site infections; however, it is important to determine the release kinetics and antimicrobial effects of drugs added to fibrin sealants and the effects of drugs on clot/clotting properties. The antimicrobial and antibiofilm activity of cefazolin, colistin, gentamicin, oxacillin, tobramycin, and silver nitrate released from fibrin sealant were characterized using in vitro and ex vivo assays against bacteria commonly found on the skin. The effects of antimicrobial agents on the physical structure of the fibrin sealant were assessed with scanning electron microscopy (SEM) and on the clotting rate and strength of fibrin clots using run-off tests and rheology.
View Article and Find Full Text PDFMolecular characterization and antimicrobial susceptibility of Corynebacterium pseudotuberculosis isolated from skin abscesses of native Korean goats (Capra hircus coreanae).
J Appl Microbiol
September 2022
Bio-Safety Research Institute, College of Veterinary Medicine, Jeonbuk National University, Iksan, Republic of Korea.
Aims: This study aimed to investigate the molecular characterization and antimicrobial susceptibility of Corynebacterium pseudotuberculosis from skin abscesses of Korean native black goats (KNBG, Capra hircus coreanae) in South Korea.
Methods And Results: A total of 83 isolates were recovered from skin abscesses of KNBG. Of these isolates, 74 isolates were identified as C.
Antimicrobial Susceptibility Profiles Among Neonatal Early-onset Sepsis Pathogens.
Pediatr Infect Dis J
March 2022
Department of Pediatrics, Emory University, Atlanta, GA.
Background: Empiric administration of ampicillin and gentamicin is recommended for newborns at risk of early-onset sepsis (EOS). There are limited data on antimicrobial susceptibility of all EOS pathogens.
Methods: Retrospective review of antimicrobial susceptibility data from a prospective EOS surveillance study of infants born ≥22 weeks' gestation and cared for in Neonatal Research Network centers April 2015-March 2017.
Impact of High-Dose Anti-Infective Agents on the Osteogenic Response of Mesenchymal Stem Cells.
Antibiotics (Basel)
October 2021
Clinic for Orthopedics and Trauma Surgery, Center for Orthopedics, Trauma Surgery and Paraplegiology, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Treatment of infected nonunions and severe bone infections is a huge challenge in modern orthopedics. Their treatment routinely includes the use of anti-infective agents. Although frequently used, little is known about their impact on the osteogenesis of mesenchymal stem cells.
View Article and Find Full Text PDFSynergy of alanine and gentamicin to reduce nitric oxide for elevating killing efficacy to antibiotic-resistant .
Virulence
December 2021
State Key Laboratory of Bio-Control and the Third Affiliated Hospital, School of Life Sciences, Southern Marine Science and Engineering Guangdong Laboratory Zhuhai, Sun Yat-sen University, University City, Guangzhou, China.
The present study explored the cooperative effect of both alanine (Ala) and gentamicin (Gent) on metabolic mechanisms by which exogenous Ala potentiates Gent to kill antibiotic-resistant . To test this, GC-MS-based metabolomics was used to characterize Ala-, Gent- and both-induced metabolic profiles, identifying nitric oxide (NO) production pathway as the most key clue to understand metabolic mechanisms. Gent, Ala and both led to low, lower and lowest activity of total nitric oxide synthase (tNOS) and level of NO, respectively.
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