AI Article Synopsis

  • Biliary fibrosis is a significant yet often overlooked aspect of liver and bile duct diseases, which can lead to serious health issues like organ failure.
  • Understanding the causes and development of biliary fibrosis is essential for improving prevention and treatment options for various biliary disorders.
  • The review highlights the clinical signs, demographics, and key cellular elements involved in biliary fibrosis, while also discussing crucial signaling pathways and future treatment strategies.

Article Abstract

Fibrosis resulting from pathological repair secondary to recurrent or persistent tissue damage often leads to organ failure and mortality. Biliary fibrosis is a crucial but easily neglected pathological feature in hepatobiliary disorders, which may promote the development and progression of benign and malignant biliary diseases through pathological healing mechanisms secondary to biliary tract injuries. Elucidating the etiology and pathogenesis of biliary fibrosis is beneficial to the prevention and treatment of biliary diseases. In this review, we emphasized the importance of biliary fibrosis in cholangiopathies and summarized the clinical manifestations, epidemiology, and aberrant cellular composition involving the biliary ductules, cholangiocytes, immune system, fibroblasts, and the microbiome. We also focused on pivotal signaling pathways and offered insights into ongoing clinical trials and proposing a strategic approach for managing biliary fibrosis-related cholangiopathies. This review will offer a comprehensive perspective on biliary fibrosis and provide an important reference for future mechanism research and innovative therapy to prevent or reverse fibrosis.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11317084PMC
http://dx.doi.org/10.1515/mr-2024-0029DOI Listing

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