Chemical syntheses of UDP-rhamnose and UDP-arabinofuranose and respective azido-modified analogues are reported. The prepared substrates are useful for the glycan array-based analysis of glycosyltransferases, as exemplified with the plant cell wall-biosynthetic enzymes XAT3, RRT4 and RRT5.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/d4cc02095b | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Spatial omics-based machine learning algorithms for the early detection of hepatocellular carcinoma.
Commun Med (Lond)
December 2024
Medical University of South Carolina, Department of Cell and Molecular Pharmacology, Charleston, SC, 29425, USA.
Background: Worldwide, hepatocellular carcinoma (HCC) is the second most lethal cancer, although early-stage HCC is amenable to curative treatment and can facilitate long-term survival. Early detection has proved difficult, as proteomics, transcriptomics, and genomics have been unable to discover suitable biomarkers.
Methods: To find new biomarkers of HCC, we utilized a spatial omics N-glycan imaging method to identify altered glycosylation in cancer tissue (n = 53) and in paired serum of individuals with HCC (n = 23).
Chemical synthesis of natural and azido-modified UDP-rhamnose and -arabinofuranose for glycan array-based characterization of plant glycosyltransferases.
Chem Commun (Camb)
August 2024
Institute of Organic Chemistry, Department of Chemistry, BOKU University, Muthgasse 18, 1190, Vienna, Austria.
Chemical syntheses of UDP-rhamnose and UDP-arabinofuranose and respective azido-modified analogues are reported. The prepared substrates are useful for the glycan array-based analysis of glycosyltransferases, as exemplified with the plant cell wall-biosynthetic enzymes XAT3, RRT4 and RRT5.
View Article and Find Full Text PDFNanowire Array Breath Acetone Sensor for Diabetes Monitoring.
Adv Sci (Weinh)
May 2024
Australian Research Council Centre of Excellence for Transformative Meta-Optical Systems, Department of Electronic Materials Engineering, Research School of Physics, The Australian National University, Canberra, ACT, 2600, Australia.
Diabetic ketoacidosis (DKA) is a life-threatening acute complication of diabetes characterized by the accumulation of ketone bodies in the blood. Breath acetone, a ketone, directly correlates with blood ketones. Therefore, monitoring breath acetone can significantly enhance the safety and efficacy of diabetes care.
View Article and Find Full Text PDFA universal dual-mode hydrogel array based on phage-DNA probe for simultaneous rapid screening and precisely quantitative detection of Escherichia coli O157:H7 in foods by the fluorescent/microfluidic chip electrophoresis methods.
Anal Chim Acta
January 2024
Key Laboratory of Advanced Mass Spectrometry and Molecular Analysis of Zhejiang Province, Institute of Mass Spectrometry, School of Material Science and Chemical Engineering, Ningbo University, Ningbo 315211, China. Electronic address:
Rapid and specific detection of virulent bacterial strains is a great challenge for food safety regarding large amounts of contaminated samples. Herein, a dual-mode hydrogel array biosensor was constructed to simultaneously rapidly screen and precisely quantitatively detect virulent Escherichia coli O157:H7 (E. coli O157:H7) based on a novel DNA-modified phage probe.
View Article and Find Full Text PDFDevelopment of an Antibody-Based Platform for the Analysis of Immune Cell-Specific N-linked Glycosylation.
Anal Chem
July 2023
Department of Cell and Molecular Pharmacology, Medical University of South Carolina, Basic Science Building Room 310, 173 Ashley Avenue, Charleston, South Carolina 29425, United States.
N-linked glycosylation plays an important role in both the innate and adaptive immune response through the modulation of cell surface receptors as well as general cell-to-cell interactions. The study of immune cell N-glycosylation is gaining interest but is hindered by the complexity of cell-type-specific N-glycan analysis. Analytical techniques such as chromatography, LC-MS/MS, and the use of lectins are all currently used to analyze cellular glycosylation.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!