AI Article Synopsis

  • Mumps is an infectious disease that can be prevented by vaccination, and its incidence was analyzed in Quzhou City after the introduction of the MMR vaccine.
  • Despite a significant reduction in mumps cases over 15 years, the highest incidence was still found in vaccinated children aged 0-12, possibly due to vaccine escape.
  • The study suggests that existing vaccines may need updates or new development to target multiple viral strains for better control, as antibody levels do not reliably indicate immunity or protection against mumps.

Article Abstract

Mumps is a vaccine-preventable acute viral infectious disease. To understand the incidence of mumps and population immunity in Quzhou City after measles mumps rubella vaccine (MMR) was included in the immunization program, we analyzed the epidemiological characteristics of mumps cases from 2009 to 2023 and a cross-sectional serosurvey of IgG antibodies to mumps conducted in 2024. We found that 15 years after the MMR vaccine was included in the immunization program, the incidence of mumps was significantly reduced in all populations, but the incidence remained highest in vaccinated children aged 0-12 years. Vaccine escape may explain the high incidence of mumps in highly vaccinated populations. Updating vaccines or developing a new vaccine that targets multiple viral genotypes may be necessary to improve the effectiveness of the vaccine against infection and fully control infections and outbreaks. The positive rate and concentration of mumps IgG antibody were inconsistent with the incidence data. mumps IgG antibody is not an ideal substitute for immunity and cannot be used to accurately predict whether a target population is susceptible or protected. Natural infections may provide longer-lasting immunity than vaccination.

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Source
http://dx.doi.org/10.1002/jmv.29856DOI Listing

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