AI Article Synopsis
- Ochratoxin A (OTA) is a harmful mycotoxin that can cause serious kidney damage in animals, highlighting the need for treatment strategies focused on the gut-kidney connection.
- This study explored the effects of inulin, a dietary fiber known to adjust intestinal bacteria and produce beneficial compounds, on kidney injuries caused by OTA in chickens.
- Results showed that inulin not only improved gut health and increased the production of protective substances, but also reduced kidney damage and inflammation, suggesting it could be a valuable approach to combat the negative effects of mycotoxins.
Article Abstract
Ochratoxin A (OTA) is a prevalent mycotoxin found in feed that causes significant kidney injury in animals. Further investigation was needed to devise strategies for treating OTA-induced kidney damage through the gut-kidney axis. Evidence indicates the crucial role of intestinal microbiota in kidney damage development. Inulin, a dietary fiber, protects kidneys by modulating intestinal microbiota and promoting short-chain fatty acid (SCFA) production. However, its precise mechanism in OTA-induced kidney damage remained unclear. In this study, chickens were orally administered OTA and inulin for 2 weeks to investigate inulin's effects on OTA-induced kidney damage and underlying mechanisms. The alteration of intestinal microbiota, SCFAs contents, and SCFA receptors was further analyzed. Results demonstrated that inulin supplementation influenced intestinal microbiota, increased SCFAs production, and mitigated OTA-induced kidney damage in chickens. The importance of microbiota in mediating inulin's renal protection was further confirmed by antibiotic and fecal microbiota transplantation experiments. Additionally, inulin exhibited antioxidant and anti-inflammatory properties, alleviating NLRP3 inflammasome activation and pyroptosis. In summary, inulin protected chickens from OTA-induced kidney damage, which might provide a potential strategy to mitigate the harmful effects of mycotoxins through prebiotics and safeguard renal health.
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| http://dx.doi.org/10.1021/acs.jafc.4c04382 | DOI Listing |
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