AI Article Synopsis
- * Adults with congenital heart disease (ACHD) face complex health challenges, as 1 in 13 may develop heart failure (HF), leading to a higher risk of hospitalizations and mortality compared to non-ACHD heart failure patients.
- * There is a significant lack of research on effective treatments for heart failure specifically in ACHD patients, making this article's review of pharmacological treatments crucial for improving care.
Article Abstract
Congenital heart disease (CHD) is the most common global congenital defect affecting over 2.4 million individuals in the United States. Ongoing medical and surgical advancements have improved the survival of children with CHD leading to a shift where, as of 2010, adults constitute two-thirds of the CHD patient population. The increasing number and aging of adult congenital heart disease (ACHD) patients present a clinical challenge due to heightened complexity, morbidity, and mortality. Studies indicate that 1 in 13 ACHD patients will develop heart failure (HF) in their lifetime. ACHD-HF patients experience more frequent emergency department visits, higher hospitalization rates, longer hospital stays, and higher mortality compared to non-ACHD patients with heart failure (non-ACHD-HF). Despite HF being the leading cause of death in ACHD patients, there is a notable gap in evidence regarding treatment. While guideline-directed medical therapy (GDMT) has been extensively studied in non-ACHD-HF, research specific to ACHD-HF individuals is limited. This article aims to comprehensively review available literature addressing the pharmacological treatment of ACHD-HF.
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| http://dx.doi.org/10.1007/s10741-024-10428-4 | DOI Listing |
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