AI Article Synopsis
- The study analyzed various immune and inflammatory indices to see how they predict in-hospital mortality in coronary care unit patients in Turkey, involving a large sample size of 3,157.
- Out of these patients, 137 (4.3%) died during their hospital stay, with significant correlations found between mortality and several indices like the systemic immune-inflammatory index (SII), C-reactive protein/albumin ratio (CAR), neutrophil-lymphocyte ratio (NLR), and prognostic nutritional index (PNI).
- Notably, when combining these indices, only the CAR significantly improved the predictive model for in-hospital mortality compared to the initial set of risk predictors.
Article Abstract
We investigated the prognostic implications of the systemic immune-inflammatory index (SII), atherogenic index of plasma (AIP), C-reactive protein/albumin ratio (CAR), neutrophil-lymphocyte ratio (NLR), prognostic nutritional index (PNI), and triglyceride/glucose index (TGI) in the MORtality predictors in the CORonary Care Units in TURKey (MORCOR-TURK) population. This is the largest registry of coronary care unit (CCU) patients in Turkey (3157 patients admitted to CCU in 50 different centers). The study population was divided into two according to in-hospital survival status; 137 patients (4.3%) died in-hospital follow-up. A significant correlation was found between death and SII, CAR, NLR, and PNI but not for AIP and TGI in logistic regression. In Model 1 (combining parameters proven to be risk predictors), the -2 log-likelihood ratio was 888.439, Nagelkerke R was 0.235, and AUC (area under curve) was 0.814 (95% CI: 0.771-0.858). All other models were constructed by adding each inflammatory marker separately to Model 1. Only Model 3 (CAR + Model 1) had a significantly greater AUC than Model 1 (DeLong = .01). Our study showed that CAR, but not other inflammatory index, is a significant predictor of in-hospital mortality in CCU patients when added to proven risk predictors.
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| http://dx.doi.org/10.1177/00033197241273389 | DOI Listing |
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