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Diffusion of Peptides and Small Molecules Encapsulated in Lipidic Cubic Phases by Band-Selective Excitation Short Transient H PGSE NMR. | LitMetric

AI Article Synopsis

  • In lipidic cubic phases (LCPs), H NMR spectra are mainly affected by water and lipid molecules, making it hard to measure the diffusion of peptides/molecules.
  • Conventional H pulsed-gradient spin-echo (PGSE) NMR struggles due to the overwhelming signals from the environment.
  • The study introduces a band-selective short transient PGSE sequence that reduces interference from water and lipids, allowing for accurate diffusion measurements of encapsulated molecules.

Article Abstract

In model membrane systems, such as lipidic cubic phases (LCPs), H NMR spectra are dominated by resonances from water and lipid molecules. The measurement of translational diffusion of peptides/molecules encapsulated in LCPs using conventional H pulsed-gradient spin-echo (PGSE) NMR is, therefore, immensely difficult due to the dynamic range caused by the intense resonance(s) from the surrounding environment. The present study reports the use of a band-selective short transient PGSE sequence, avoiding the perturbation of both hydration water and lipids, for measuring the diffusion of molecules encapsulated within the lipid bilayer and the aqueous channels of LCPs.

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Source
http://dx.doi.org/10.1021/acs.jpclett.4c01894DOI Listing

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