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Assessment of MpoxPlex, a high-throughput and multiplexed immunoassay: a diagnostic accuracy study.
Lancet Microbe
January 2025
Emerging Pathogen Serology Group, Vaccine Development Evaluation and Preparedness Centre, UK Health Security Agency, Wiltshire, UK.
Background: In May, 2022, the first global outbreak of mpox (formerly known as monkeypox) occurred. In response, public health agencies in the UK have made smallpox vaccines available to individuals at the highest risk of infection. With mpox cases still being detected globally, novel tools are required to aid with diagnosis, serosurveillance, and the evaluation of immune responses following infection and immunisation with current and new vaccine candidates.
View Article and Find Full Text PDFImpacts of seasonality on mercury concentrations, polyunsaturated fatty acids, and stable isotopes: implications for the use of tetragnathid spiders as sentinels.
Environ Toxicol Chem
January 2025
Molecular Biosciences PhD Program, Middle Tennessee State University, Murfreesboro, TN, United States.
Riparian spiders are used in ecotoxicology as sentinels of bioavailable contaminants that are transferred from aquatic to terrestrial habitats via emergent aquatic insects. Spiders in the family Tetragnathidae are particularly of interest because a high proportion of their diet consists of emergent aquatic insects and their contaminant loads reflect the amount transferred through the food web to riparian predators. The transfer of contaminants can be determined through food web tracers such as stable isotopes and polyunsaturated fatty acids; however, it is unclear how contaminants and tracers vary over the course of a year.
View Article and Find Full Text PDFalpha toxin enteritis associated with pulmonary disease in a neotropical otter (, Olfers, 1818) under human care.
Braz J Vet Med
December 2024
Veterinarian, DSc. DMCV, IV, UFRRJ. Seropédica, RJ, Brazil.
alpha toxin (CPA) is an important enterotoxemic pathogen linked to gastrointestinal disorders and previously associated with pulmonary disease in other mammals. A young female neotropical otter presented with lethargy, anorexia and steatorrhea, which developed within 24 hours. Veterinary care was provided under anesthesia, during which dehydration, intestinal hypermotility and pulmonary crackling sounds were identified.
View Article and Find Full Text PDFMarine Protected Areas That Preserve Trophic Cascades Promote Resilience of Kelp Forests to Marine Heatwaves.
Glob Chang Biol
December 2024
Hopkins Marine Station and Oceans Department, Stanford University, Pacific Grove, California, USA.
Under accelerating threats from climate-change impacts, marine protected areas (MPAs) have been proposed as climate-adaptation tools to enhance the resilience of marine ecosystems. Yet, debate persists as to whether and how MPAs may promote resilience to climate shocks. Here, we use 38 years of satellite-derived kelp cover to empirically test whether a network of 58 temperate coastal MPAs in Central and Southern California enhances the resistance of kelp forest ecosystems to, and their recovery from, the unprecedented 2014-2016 marine heatwave regime that occurred in the region.
View Article and Find Full Text PDFTRIM4 enhances small-molecule-induced neddylated-degradation of CORO1A for triple negative breast cancer therapy.
Theranostics
December 2024
Shanghai Frontiers Science Center for Chinese Medicine Chemical Biology; Institute of Interdisciplinary Integrative Medicine Research and Shuguang Hospital; Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
As a critical member of the Coronin family, Coronin 1A (CORO1A) plays a crucial role in the progression of triple-negative breast cancer (TNBC). However, CORO1A is typically considered "undruggable" due to its smooth surface and complex protein-protein interactions (PPIs). Molecular glues have emerged as one of the most effective strategies to rapidly degrade such "undruggable" targets.
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