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Interleukin-10 suppresses lipid metabolism-mediated intestinal inflammation. | LitMetric

Interleukin-10 suppresses lipid metabolism-mediated intestinal inflammation.

Life Metab

Division of Immunology and Division of Gastroenterology, Harvard Medical School and Boston Children's Hospital, Boston, MA 02115, United States.

Published: June 2024

In a recent paper published in , York . reported that the anti-inflammatory cytokine IL-10 regulates sphingolipid metabolism to limit NF-κB-mediated inflammation. Deletion of in mice, or genetic mutation of in humans, predisposes to inflammatory bowel disease, which may be overcome by restoring homeostatic sphingolipid metabolism.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11315366PMC
http://dx.doi.org/10.1093/lifemeta/loae011DOI Listing

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