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| http://dx.doi.org/10.1016/j.jscai.2022.100036 | DOI Listing |
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Validating International Classification of Diseases Code 10th Revision algorithms for accurate identification of pulmonary embolism.
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YNHH/Yale Center for Outcomes Research and Evaluation, New Haven, Connecticut, USA; Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA; Department of Health Policy and Management, Yale School of Public Health, New Haven, Connecticut, USA.
Background: Many research investigations for pulmonary embolism (PE) rely on the International Classification of Diseases 10th Revision (ICD-10) codes for analyses of electronic databases. The validity of ICD-10 codes in identifying PE remains uncertain.
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ApoA-I Infusions and Burden of Ischemic Events After Acute Myocardial Infarction: Insights From the AEGIS-II Trial.
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November 2024
Weill Cornell Medicine, New York, New York, USA.
Background: Following an acute myocardial infarction (AMI), patients remain at risk for subsequent cardiovascular (CV) events. In the AEGIS-II trial, CSL112, a human apolipoprotein A-I derived from plasma that enhances cholesterol efflux, did not significantly reduce the first occurrence of CV death, myocardial infarction (MI), or stroke through 90 days compared with placebo. However, an analysis involving only the first event may not capture the totality of the clinical impact of an intervention because patients may experience multiple events.
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Optical Modification of a Nanoporous Alumina Structure Associated with Surface Coverage by the Ionic Liquid AliquatCl.
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Departamento de Física Aplicada I, Facultad de Ciencias, Universidad de Málaga, 29071 Málaga, Spain.
This manuscript analyses changes in the optical parameters of a commercial alumina nanoporous structure (Anodisc or AND support) due to surface coverage by the ionic liquid (IL) AliquatCl (AlqCl). XPS measurements were performed for chemical characterization of the composite AND/AlqCl and the AND support, but XPS resolved angle analysis (from 15° to 75°) was carried out for the homogeneity estimation of the top surface of the ANDAlqCl sample. Optical characterization of both the composite AND/AlqCl and the AND support was performed by three non-destructive and non-invasive techniques: ellipsometry spectroscopy (SE), light transmittance/reflection, and photoluminescence.
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Article Synopsis
- * The study involved over 18,000 patients who were randomly assigned to receive either CSL112 or a placebo, showing that CSL112 resulted in a numerical decrease in rates of cardiovascular death and recurrent MIs over 1 year.
- * While CSL112 did not significantly meet the primary endpoint goals, the results suggest it may help reduce the risk of heart-related complications, indicating a potential benefit of apoA-I in managing cholesterol and plaque stability in at-risk patients.
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