Inositol phosphates are critical signaling messengers involved in a wide range of biological pathways in which inositol polyphosphate multikinase (IPMK) functions as a rate-limiting enzyme for inositol polyphosphate metabolism. IPMK has been implicated in cellular metabolism, but its function at the systemic level is still poorly understood. Since skeletal muscle is a major contributor to energy homeostasis, we have developed a mouse model in which skeletal muscle IPMK is specifically deleted and examined how a loss of IPMK affects whole-body metabolism. Here, we report that mice in which IPMK knockout is deleted, specifically in the skeletal muscle, displayed an increased body weight, disrupted glucose tolerance, and reduced exercise tolerance under the normal diet. Moreover, these changes were associated with an increased accumulation of triglyceride in skeletal muscle. Furthermore, we have confirmed that a loss of IPMK led to reduced beta-oxidation, increased triglyceride accumulation, and impaired insulin response in IPMK-deficient muscle cells. Thus, our results suggest that IPMK mediates the whole-body metabolism via regulating muscle metabolism and may be potentially targeted for the treatment of metabolic syndromes.
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http://dx.doi.org/10.1101/2024.07.28.605526 | DOI Listing |
Front Physiol
January 2025
School of Kinesiology, Auburn University, Auburn, AL, United States.
Nitric oxide (NO) is a ubiquitous signaling molecule known to modulate various physiological processes, with specific implications in skeletal muscle and broader applications in exercise performance. This review focuses on the modulation of skeletal muscle function, mitochondrial adaptation and function, redox state by NO, and the effect of nitrate supplementation on exercise performance. In skeletal muscle function, NO is believed to increase the maximal shortening velocity and peak power output of muscle fibers.
View Article and Find Full Text PDFFront Med (Lausanne)
January 2025
Department of General Surgery, Baskent University, Istanbul, Türkiye.
Introduction: Various reports have confirmed that low skeletal muscle mass, a proxy marker of sarcopenia, can be a risk factor for surgical and oncological outcomes in colon cancer. We aimed to investigate the effects of skeletal muscle mass index (SMMI) on postoperative complications, overall survival (OS), and disease-free survival (DFS) in older patients with colon cancer who underwent elective curative colon resections.
Materials And Methods: Patients over 65 years old with stage I-III colon cancer who underwent elective curative colon resections between January 2015 and December 2023 were included in this single-center retrospective longitudinal study.
BMC Musculoskelet Disord
January 2025
Department of Anatomy, School of Life Dentistry at Niigata, Nippon Dental University, Niigata, Japan.
Background: The purpose of this study was to clarify the relationships of the tibialis anterior tendon (TAT) and peroneus longus tendon (PLT) with articular cartilage degeneration on the medial cuneiform and first metatarsal.
Methods: We examined 100 feet from 50 Japanese cadavers. The TAT was classified into 4 types based on attachment site area and number of fiber bundles: Type I, two fiber bundles with equal (within 20%) attachment site areas on the first metatarsal and medial cuneiform; Type II, with two fiber bundles and a larger (>20%) attachment site area on the medial cuneiform than on the first metatarsal; Type III, with two fiber bundles and a larger (>20%) attachment site area on the first metatarsal than on the medial cuneiform; and Type IV, with three fiber bundles.
BMC Nephrol
January 2025
Department of Nephrology, Zhabei Central Hospital of Jing'an District, No. 619 Zhonghua New Road, Shanghai, 20070, China.
Background: Osteoporosis and sarcopenia frequently occur in patients with end-stage renal disease undergoing hemodialysis (HD), and depression is also a common mental health issue in this population. Despite the prevalence of these conditions, the interrelationships among them remain poorly understood in HD patients.
Methods: In this multicenter cross-sectional study, 858 HD patients from 7 dialysis centers were recruited.
Trends Mol Med
January 2025
Body-Brain-Mind Laboratory, School of Psychology, Shenzhen University, Shenzhen, 518060, China. Electronic address:
Regular physical activity (PA) is beneficial for cognitive health, and cathepsin B (CTSB) - a protease released by skeletal muscle during PA - acts as a potential molecular mediator of this association. PA-induced metabolic and mechanical stress appears to increase plasma/serum CTSB levels. CTSB facilitates neurogenesis and synaptic plasticity in brain regions (e.
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