The development of a late fistula between a native unremoved corrosively altered oesophagus and the right lung with subsequent chronic lung abscess formation 34 years after retrosternal colo-oesophagoplasty is an extremely rare complication. According to our review of the English-language literature, such a case has not been described so far. We present a 50-year-old man with complaints of dry cough, periodic epigastric postprandial pain, regurgitation of food and halitosis, which started about seven years ago. Transthoracic right-sided subtotal oesophagectomy and resection of the sixth lung segment were performed. Diagnostics and surgical treatment are discussed.
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http://dx.doi.org/10.7759/cureus.64362 | DOI Listing |
Nat Commun
December 2024
Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
The mechanism(s) underlying gut microbial metabolite (GMM) contribution towards alcohol-mediated cardiovascular disease (CVD) is unknown. Herein we observe elevation in circulating phenylacetylglutamine (PAGln), a known CVD-associated GMM, in individuals living with alcohol use disorder. In a male murine binge-on-chronic alcohol model, we confirm gut microbial reorganization, elevation in PAGln levels, and the presence of cardiovascular pathophysiology.
View Article and Find Full Text PDFBrain Commun
December 2024
San Diego Biomedical Research Institute, San Diego, CA 92121, USA.
Hypoxia triggers blood-brain barrier disruption and a strong microglial activation response around leaky cerebral blood vessels. These events are greatly amplified in aged mice which is translationally relevant because aged patients are far more likely to suffer hypoxic events from heart or lung disease, and because of the pathogenic role of blood-brain barrier breakdown in vascular dementia. Importantly, it is currently unclear if disrupted cerebral blood vessels spontaneously repair and if they do, whether surrounding microglia deactivates.
View Article and Find Full Text PDFIran J Microbiol
December 2024
Department of Parasitology and Mycology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Background And Objectives: Airway fungal infection is a severe clinical problem, especially in patients with compromised immune functions. Here, we examined the distribution and antifungal susceptibility profiles of fungal agents isolated from respiratory tract of symptomatic patients hospitalized in pulmonary units.
Materials And Methods: This descriptive cross-sectional study took place from 2023 to 2024, involving 360 patients.
Front Immunol
December 2024
Priority Area Chronic Lung Diseases, Research Center Borstel - Leibniz Lung Center, Members of the German Center for Lung Research (DZL), Borstel, Germany.
Introduction: Autoantibody-mediated complement activation plays an essential role in a variety of autoimmune disorders. However, the role of complement in systemic sclerosis (SSc) remains largely unknown. In this study, we aimed to determine the role of complement C3 in the development of a recently described SSc mouse model based on autoimmunity to angiotensin II receptor type 1 (AT1R).
View Article and Find Full Text PDFFront Nutr
December 2024
Department of Pulmonary and Critical Care Medicine, Xinxiang Central Hospital, Xinxiang, China.
Background: Previous studies have demonstrated that the Naples Prognostic Score (NPS) provides strategic direction in the prognosis of malignant illness. Nevertheless, its relationship with chronic obstructive pulmonary disease (COPD) remains underexplored. Therefore, additional research specifically focusing on the relationship between the Naples Prognostic Score and COPD is necessary to determine its widespread applicability.
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