AI Article Synopsis
- - The study investigated the combined effects of hydroxyapatite (HA) and zirconium oxide (ZrO) coatings on titanium, focusing on promoting osteoblast activity and antibacterial properties.
- - Four groups were tested: a control with smooth titanium and three experimental groups with different surface treatments including HA and ZrO coatings, with assessments for cell adhesion and osteoblast behavior.
- - Results indicated that the double-layered HA and ZrO coating significantly reduced bacterial adhesion and improved osteoblastic viability and differentiation, with the best outcomes observed in the group with both coatings (Group ZH).
Article Abstract
Purpose: This study aimed to confirm the synergy effect of these two materials by evaluating osteoblast and antibacterial activity by applying a double-layered hydroxyapatite(HA) zirconium oxide(ZrO) coating to titanium.
Methods: The specimens used in this study were divided into four groups: a control group (polished titanium; group T) and three experimental groups: Group TH (RF magnetron sputtered HA deposited titanium), Group Z (ZrO ALD deposited titanium), and Group ZH (RF magnetron sputtered HA and ZrO ALD deposited titanium). The adhesion of () to the surface was assessed using a crystal violet assay. The adhesion, proliferation, and differentiation of MC3T3-E1 cells, a mouse osteoblastic cell line, were assessed through a WST-8 assay and ALP assay.
Results: Group Z showed a decrease in the adhesion of ( < 0.05) and an improvement in osteoblastic viability ( < 0.0083). Group TH and ZH showed a decrease in adhesion of ( < 0.05) and an increase in osteoblastic cell proliferation and cell differentiation ( < 0.0083). Group ZH exhibited the highest antibacterial and osteoblastic differentiation.
Conclusion: In conclusion double-layered HA and ZrO deposited on titanium were shown to be more effective in inhibiting the adhesion of , which induced biofilm formation, and increasing osteoblastic differentiation involved in osseointegration by the synergistic effect of the two materials.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11316491 | PMC |
| http://dx.doi.org/10.2147/IJN.S470231 | DOI Listing |
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