AI Article Synopsis
- The Fontan operation is the preferred surgical treatment for patients with univentricular physiology, but it is only a temporary solution that leads to complications as they reach adulthood.
- These patients often face severe health issues, such as liver failure and arrhythmias, and heart transplantation is the ideal treatment, although it is frequently delayed and complicated by donor shortages.
- Mechanical circulatory support options are emerging as potential solutions, with ongoing research into intravascular pumps, but they currently require high-risk surgeries and are still experimental.
Article Abstract
Even if the Fontan operation is the surgical treatment of choice in patients with univentricular physiology, it remains a palliative strategy. Consequently, when Fontan patients reach adulthood, the majority of them develop late clinical sequelae of a failing cavo-pulmonary circuit (eg, liver failure, protein-losing enteropathy, and arrhythmias). Although heart transplantation represents the gold standard to treat this condition, Fontan patients usually accede to this therapy late, when risk of mortality is significantly increased, and a shortage of donor hearts limits transplantation in this special population. Mechanical circulatory support is an emerging field, but it is still in the experimental stage. Current mechanical circulatory devices have been used in Fontan circulation but are associated with the need for high-risk redo surgery. Percutaneous pumps are an emerging field that is still under investigation, with multiple prototypes developed. This review aims to analyze the hemodynamic profile of the developed intravascular pumps and their application in the preclinical scenario in the Fontan circulation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11307829 | PMC |
| http://dx.doi.org/10.1016/j.jscai.2024.101334 | DOI Listing |
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