AI Article Synopsis
- New-onset refractory status epilepticus (NORSE) is a serious condition that can cause significant disability, often not responding well to standard treatments.
- An 11-year-old girl with anti-GAD 65 encephalitis who experienced NORSE showed minimal improvement with regular anti-seizure medications and first-line therapies.
- After receiving intrathecal dexamethasone (IT-DEX) along with rituximab, her neuroinflammation decreased, seizure frequency dropped, and she could reduce anesthesia, suggesting IT-DEX could be beneficial early on for various causes of refractory status epilepticus.
Article Abstract
New-onset refractory status epilepticus (NORSE) is a devastating clinical condition that often leads to severe disability. Intrathecal dexamethasone (IT-DEX) has been reported to improve refractory status epilepticus. We present an 11-year-old female with anti-GAD 65 encephalitis presenting as NORSE who had minimal response to standard anti-seizure medications and first-line immunotherapies. The patient received 6 doses of IT-DEX in conjunction with rituximab which correlated with subsequent decreased neuroinflammation, reduced seizure burden and aided in weaning anesthetic infusions. Our case with literature review suggests IT-DEX may be utilized as an early intervention in those with refractory status epilepticus from various etiologies.
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| http://dx.doi.org/10.1016/j.jneuroim.2024.578430 | DOI Listing |
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